Advances in the Synthesis of Cyclopropylamines

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Cyclopropylamines are an important subclass of substituted cyclopropanes that combine the unique electronic and steric properties with presence a donor nitrogen atom. In addition to their in diverse array biologically active compounds, cyclopropylamines utilized as synthetic intermediates, particularly ring-opening or cycloaddition reactions. Consequently, synthesis these compounds has constituted significant research topic, evidenced by abundant published methods. widely used Curtius rearrangement, classical cyclopropanation methods have been adapted integrate function (Simmons-Smith reaction, metal-catalyzed reaction diazo on olefins, Michael-initiated ring-closure reactions) advances enantioselective synthesis. More recently, specific developed for preparation aminocyclopropane moiety (Kulinkovich reactions applied amides nitriles, cyclopropenes, involving C-H functionalization, ...). The topic this review is present different cyclopropylamine derivatives, aim covering methodological best possible, highlighting scope, stereochemical aspects future trends.

Язык: Английский

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Acylsilanes as Weakly Coordinating Directing Groups for Metal-Catalyzed C–H Functionalization

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 6881 - 6894

Опубликована: Апрель 14, 2025

Язык: Английский

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Benzocyclobutenone Synthesis Exploiting Acylsilanes as Photofunctional Directing Groups

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The visible-light irradiation of acylsilane tethered vinyl ketones promotes an intramolecular Stetter-type reaction

Язык: Английский

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Photochemistry of 2-(2-Formylphenyloxy)acetic Acid Derivatives: Synthesis of Hydroxychromanones and Benzofuranones

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(38), С. 7848 - 7853

Опубликована: Янв. 1, 2024

2-(2-Formylphenoxy)acetic acid and its esters undergo photocyclization into chromanone benzofuranone derivatives under 365 nm irradiation.

Язык: Английский

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Theoretical Exploration of Siloxy Carbenes: Photogeneration and [2+1] Photocyclization Mechanisms

Physical Chemistry Chemical Physics, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Regulatory mechanisms for the photogeneration of singlet/triplet siloxy carbenes and their involvement in [2+1] photocyclizations have been thoroughly studied at CASPT2//CASSCF/PCM level theory.

Язык: Английский

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Graphisches Inhaltsverzeichnis: Angew. Chem. 47/2023

Angewandte Chemie, Год журнала: 2023, Номер 135(47)

Опубликована: Ноя. 14, 2023

…full-length Max transcription factor variants with distinct modifications was prepared to investigate the impact of Ser phosphorylation, as reported by Ariel Afek, Muhammad Jbara et al. in their Research Article (e202310913).Comprehensive DNAbinding analysis and high-throughput screening revealed that phosphorylation pattern plays ac rucial role DNA-binding activity but does not affect sequence specificity.T he insights gained into regulatory shed light on how post-translational influence activity. BatteriesIn (e202310976), Ryoichi Kanega, Akira Yamamoto report an aqueous redox flow battery using CO 2 active material ahomogeneous Ir catalyst. BatteriesReversible six-electron transfer cathode for zinc batteries is Zhiqiang Zhu Communication (e202312000).

Язык: Английский

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Graphical Abstract: Angew. Chem. Int. Ed. 47/2023

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(47)

Опубликована: Ноя. 14, 2023

Kanega, Akira Yamamoto et al. report an aqueous redox flow battery using CO 2 as active material with ahomogeneous Ir catalyst.

Язык: Английский

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