Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(4), С. 54 - 68
Опубликована: Авг. 25, 2024
Current
advances
in
knowledge
about
peptides
as
drugs
are
of
great
significance;
They
have
planning
potentialities
different
sections
medicinal
practice.
This
review
will
summarize
the
progress
synthesis
and
biological
activities
peptide-based
drug,
along
with
some
uses.
We
start
historical
aspect
key
points
development
corresponding
field.
In
general,
part
describes
approaches
synthesis,
design
strategies,
screening
methods,
optimization
for
stability
bioavailability.
then
describe
action
such
mechanisms
respect
to
receptors,
enzymes,
that
can
penetrate
cells.
It
has
also
expanded
assessment
description
peptide
treatment
cancer,
cardiovascular
diseases,
metabolic
neurological
infectious
immunotherapy.
cover
both
problems
formation
like
stability,
delivery,
regulatory
issues
opportunities
nanotechnology,
bioprinting,
CRISPR.
Last,
we
discuss
outlook
therapeutics
features,
which
promising
new
trends
perspectives
application.
The
present
is
intended
give
an
up-to-date
easy
grasp
information
regarding
status
peptide-associated
medicines
contemporary
pharmacology.
Ultrasonics Sonochemistry,
Год журнала:
2025,
Номер
114, С. 107257 - 107257
Опубликована: Фев. 7, 2025
The
integration
of
low-frequency
ultrasound
with
Solid-Phase
Peptide
Synthesis
(SPPS)
was
explored
to
establish
a
Sustainable
Ultrasound-assisted
(SUS-SPPS)
method.
This
innovative
approach
significantly
reduces
solvent
consumption,
washing
steps,
time,
and
reagent
usage
compared
conventional
manual
SPPS
protocols.
SUS-SPPS
method
exploits
at
every
stage
synthesis
work-up,
reducing
the
process
just
two
steps.
first
step
sequentially
combines
Fmoc-amino
acid
coupling,
capping
unreacted
amino
groups,
Fmoc
deprotection
into
single
operation,
while
second
one
consists
procedure.
Moreover,
we
demonstrated
that
is
compatible
various
resin
types,
including
Rink-amide,
Wang,
Cl-Trt
resins,
facilitates
efficient
peptides
varying
lengths
(up
20-mers)
compositions,
those
traditionally
considered
"difficult
sequences",
excellent
yields
purity.
Notably,
per
coupling
cycle
by
83-88%,
marking
significant
breakthrough
in
sustainable
peptide
synthesis.
While
the
allyloxycarbonyl
(Alloc)
protecting
group
has
played
a
key
role
in
solid-phase
peptide
synthesis
(SPPS),
providing
access
to
wide
range
of
peptides,
its
removal
suffered
from
relying
on
air-sensitive
Pd(0)
complexes
hazardous
solvents.
We
report
metal-free,
on-resin
Alloc
using
readily
available
iodine/water
environmentally
sensible
PolarClean
(PC)/ethyl
acetate
(EtOAc)
carried
out
one-pot
manner
with
racemization-free
couplings
employing
both
9-fluorenylmethoxycarbonyl
(Fmoc)
and
amino
acids
(AAs).
SPPS
been
demonstrated
by
performing
consecutive
removals–peptide
couplings,
whereas
compatibility
long
peptides
proven
carrying
an
removal–coupling
39
AA
resin.
Upscaling
10
g
was
combined
TFA-free
resin
cleavage,
opening
up
opportunities
for
Alloc-AAs
as
synthons
sustainable
manufacturing.
Science Translational Medicine,
Год журнала:
2025,
Номер
17(791)
Опубликована: Март 26, 2025
Peptide
YY
(PYY
3–36
)
has
attracted
attention
in
diabetes
and
obesity
research
because
of
its
involvement
food
intake
regulation
glucose
homeostasis.
Native
PYY
maintains
high
potency
on
the
Y
2
receptor
with
a
loss
1
,
4
5
receptors.
However,
relatively
short
half-life,
selectivity
displayed
by
native
peptide
may
not
be
optimal
if
long-acting
analog
is
to
developed.
We
performed
variant
screening
identify
key
canonical
amino
acids
that
are
pivotal
selectivity,
potency,
stability.
In
combination
fatty
diacid
derivatization,
this
afforded
highly
selective
analogs
against
receptor,
which
improved
metabolism
diabetic
db
/
mice.
When
combined
glucagon-like
(GLP-1)
agonist,
these
showed
superior
blood
lowering
ZSF1
rats
greater
body
weight
high-fat
diet–induced
mouse
model
compared
treatment
GLP-1
alone.
One
tested
analogs,
PYY1875,
progressed
into
clinical
trials
for
obesity.
Together,
our
results
demonstrate
power
derivatization
development
long-acting,
efficacious
candidate.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Chemical
process
development
is
a
critical
component
in
the
for
active
pharmaceutical
ingredients
(APIs).
With
interfaces
to
drug
discovery
and
API
manufacturing,
chemical
activities
must
deliver
scalable,
safe,
cost-efficient,
sustainable,
reliable
processes
novel
as
well
marketed
APIs.
Despite
its
importance
industry
society,
domain
of
development,
together
with
advances
challenges,
often
not
known
nonpractitioners.
As
scientists,
we
provide
scientific
perspective
on
state
affairs
which
believe
will
be
value
broader
audience,
including
academic
researchers,
students,
professionals
from
related
fields.
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Chemical
process
development
is
a
critical
component
in
the
for
active
pharmaceutical
ingredients
(APIs).
With
interfaces
to
drug
discovery
and
API
manufacturing,
chemical
activities
must
deliver
scalable,
safe,
cost‐efficient,
sustainable,
reliable
processes
novel
as
well
marketed
APIs.
Despite
its
importance
industry
society,
domain
of
development,
together
with
advances
challenges,
often
not
known
nonpractitioners.
As
scientists,
we
provide
scientific
perspective
on
state
affairs
which
believe
will
be
value
broader
audience,
including
academic
researchers,
students,
professionals
from
related
fields.
