TFA-Promoted Cascade Sulfonylation/Rearrangement/Cyclization of 1,5-Diynols and Sodium Sulfinates to Construct Sulfonylated Benzo[b]fluorenes
Shimin Jiang,
Meng Liang,
Jiang Bai
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(9), С. 6416 - 6427
Опубликована: Апрель 15, 2024
A
novel
conversion
of
1,5-diynols
into
sulfonylated
benzo[b]fluorenes
is
reported
by
a
TFA-promoted
cascade
cyclization
with
sodium
sulfinates
under
mild
conditions.
This
strategy
provides
an
efficient
and
practical
approach
for
accessing
various
sulfonated
in
moderate
to
excellent
yields
metal-free
On
the
basis
control
experimental
results
density
functional
theory
calculations,
possible
transformation
mechanism
consisting
dehydration
propargylic
alcohols,
sulfonylation,
allenylation,
Schmittel-type
proposed.
It
worth
noting
that
TFA
played
important
role
this
cyclization,
which
promoted
C–SO2R
bond
cleavage
sulfone
intermediate
form
allenyl
sulfones,
followed
give
target
product.
Язык: Английский
Recent Advances on Direct Phosphorothiolation Reactions
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 23, 2024
Abstract
Organophosphorothioates
are
organic
molecules
containing
sulfur
and
phosphorus,
with
significant
biological
activity
physicochemical
properties,
widely
used
in
synthesis,
medicinal
chemistry,
the
agrochemical
industry.
In
particular,
many
phosphorothioates
display
a
variety
of
activities,
such
as
antifungal,
antibacterial,
anti‐parasite,
anticancer,
so
on.
Traditionally,
synthesis
has
mainly
relied
on
indirect
methods
involving
construction
S−P
bond.
recent
years,
direct
phosphorothiolation
gained
attention
reliable
rapid
method
for
introducing
−S−P(O)(OR)
2
group
into
parent
molecules.
This
article
reviews
latest
advances
reactions,
categorized
based
different
sources
group.
Язык: Английский
Iron-catalyzed cascade cyclization of diaryldiyn-3-ones with P(O)H compounds: a rapid method for accessing 10-phosphorylated benzo[b]fluorenones
Yinwei Cao,
Yue Ying,
Jie‐Yi Wu
и другие.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 4997 - 5002
Опубликована: Янв. 1, 2024
The
first
iron-catalyzed
cascade
cyclization
of
diaryldiyn-3-ones
with
P(O)H
compounds
for
the
synthesis
10-phosphorylated
benzo[
b
]fluorenones
is
presented.
Язык: Английский
New Frontiers in Phosphorothioate Formation: Harnessing Inorganic Phosphorus Sources
Chemical Communications,
Год журнала:
2024,
Номер
60(99), С. 14691 - 14702
Опубликована: Янв. 1, 2024
This
review
highlights
the
latest
advancements
in
synthesis
of
phosphorothioates
and
their
derivatives
from
inorganic
phosphorus
sources,
focusing
on
applicability,
mechanisms,
current
limitations,
potential
future
directions.
Язык: Английский
Synthesis of Unsymmetrical Phosphorus Disulfides
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(36), С. 7492 - 7499
Опубликована: Янв. 1, 2024
A
sulfur-mediated
umpolung
strategy
employing
Язык: Английский
Recent Advances in the Cascade Cyclization of Alkyne Units for the Construction of Benzofluorenes
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(22), С. 4585 - 4605
Опубликована: Окт. 11, 2024
Abstract
Benzofluorenes
are
an
important
class
of
polycyclic
aromatic
hydrocarbons
(PAHs),
which
widely
used
in
materials
science
for
light‐sensitive
electronic
components.
In
addition,
the
benzofluorene
skeleton
also
serves
as
a
key
structural
unit
various
natural
products.
Therefore,
development
synthetic
strategies
construction
benzofluorenes
has
been
prominent
research
topic
chemistry.
Over
past
few
decades,
numerous
efforts
have
made
via
cascade
cyclization
alkyne
units.
This
review
aims
to
summarize
recent
advances
units
Based
on
different
reaction
mechanisms
underlying
these
transformations,
this
can
be
divided
into
four
categories:
(1)
thermal‐induced
benzofluorenes,
(2)
metal‐catalyzed
(3)
acid‐promoted/catalyzed
and
(4)
base‐promoted
benzofluorenes.
Язык: Английский