Copper-Catalyzed Synthesis of 4-CF3-1,2,3-Triazoles: An Efficient and Facile Approach via Click Reaction

Molecules, Год журнала: 2024, Номер 29(6), С. 1191 - 1191

Опубликована: Март 7, 2024

Incorporation of a trifluoromethyl group with 1,2,3-triazoles motifs was described. We explored click reaction approach for regioselective synthesis 1-susbstituted-4-trifluoromethyl-1,2,3-triazoles in which 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) reacts commercial 2-bromo-3,3,3-trifluoropropene (BTP) to form 3,3,3-trifloropropyne (TFP) situ. Arising from merits associated the availability and stability BTP, high efficiencies CuI/1,10-Phenanthroline (Phen)-catalyzed cycloaddition reactions azides alkynes, this readily performed process takes place target yields, wide azide substrate scope. The potential value protocol demonstrated by its application gram-scale reaction.

Язык: Английский

Regioselective 3-Trifluoromethylated Pyrrole Synthesis Using 2‑Bromo-3,3,3-trifluoropropene (BTP)

Synfacts, Год журнала: 2023, Номер 20(01), С. 0010 - 0010

Опубликована: Дек. 8, 2023

Язык: Английский