Copper-Catalyzed Domino Annulation of Isoselenocyanates: A Pathway to Structurally Diverse N, Se-Bis-Heterocyclic, and Fused Heterocyclic Compounds
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
A
copper-catalyzed
domino
addition/cyclization
reaction
was
developed
to
synthesize
novel
benzoselenazole-linked
1,2,3-triazole
and
tetracyclic
fused
12H-benzo[4,5]selenazole[2,3-b]quinazolin-12-one
derivatives
from
isoselenocyanates.
This
efficiently
constructed
multiple
new
chemical
bonds
in
a
single
step,
forming
either
four
(one
C–Se
three
C–N)
or
two
bonds.
The
offers
several
key
advantages,
including
mild
conditions,
broad
substrate
compatibility,
straightforward
safe
operation.
It
presents
method
for
synthesizing
N,
Se-containing
polycyclic
compounds,
which
have
potential
interest
medicinal
chemistry.
Notably,
some
of
the
synthesized
compounds
exhibited
anticancer
activity
with
IC50
values
below
20
μmol
L–1
against
T24
human
bladder
cancer
cells.
Язык: Английский
Electro-Oxidative Three-Component Synthesis of 3,5-Disubstituted-1,2,4-Thiadiazoles from Amines, Amidines, and CS2
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 29, 2025
1,2,4-Thiadiazoles,
a
significant
class
of
heterocyclic
compounds,
are
widely
found
in
biologically
active
molecules.
Herein,
we
report
green
electrochemical
three-component
reaction
amines,
amidines,
and
CS2
for
the
effective
synthesis
3,5-disubstituted-1,2,4-thiadiazoles
under
metal-
oxidant-free
conditions.
Both
aliphatic
aryl
amines
well-tolerated
at
room
temperature
simple
undivided
cell.
A
series
1,2,4-thiadiazoles
prepared
with
excellent
functional
groups.
Язык: Английский