Synthesis of Acylbenzo[b]thiophenes, Benzofurans and Indoles via Intramolecular Oxidative Cyclization Enabled by Photocatalytic Hydrogen Atom Transfer (HAT)
Tetrahedron Chem,
Год журнала:
2025,
Номер
unknown, С. 100119 - 100119
Опубликована: Янв. 1, 2025
An
efficient
strategy
for
intramolecular
oxidative
cyclization
of
2-alkynylthioanisoles
toward
3-acylbenzo[b]thiophenes
by
photochemical
hydrogen
atom
transfer
catalysis
has
been
developed.
3-Acylbenzo[b]selenophenes,
benzofurans
and
indoles
can
also
be
prepared
this
protocol.
This
reaction
is
convenient
to
perform
at
room
temperature
under
simple
conditions
using
air
as
the
oxidant.
Mechanistic
studies
revealed
that
formation
α-thioalkyl
radicals
intermediate
crucial.Graphical
abstract
Язык: Английский
Sustainable Synthesis through Catalyst‐Free Photoinduced Cascaded Bond Formation
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
19(14)
Опубликована: Май 8, 2024
The
beginning
of
photochemical
reactions
revolutionized
synthetic
chemistry
through
sustainable
practices.
This
review
explores
cutting-edge
developments
in
leveraging
light-induced
processes
for
generating
cascaded
C-C
and
C-hetero
bonds
without
catalysts.
Significantly,
catalyst-free
photoinduced
methodologies
have
garnered
considerable
attention,
especially
the
creation
varied
heterocyclic
frameworks
drug
design
synthesis
natural
products.
article
delves
into
underlying
mechanisms,
addresses
limitations,
evaluates
various
methodologies,
emphasizing
potential
photocatalyst
transition
metal-free
to
enhance
sustainability.
Divided
two
sections,
it
covers
recent
strides
C-heteroatom
multiple
bond
formation
reactions.
Язык: Английский
Photoinduced Metal‐Free Decarboxylative Fluoroalkylation of Alkenes for the Synthesis of N‐Arylbutanamides and Oxindoles
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(68)
Опубликована: Авг. 28, 2024
The
visible
light-induced
decarboxylative
cascade
reaction
of
fluoroalkyl
carboxylic
acids
has
been
achieved
for
the
efficient
synthesis
fluorinated
compounds.
However,
most
transformations
rely
on
noble
iridium
metal
complex.
Herein,
a
metal-free
realized.
This
protocol
features
simple
operation,
transition
free,
and
good
functional
group
tolerance.
Язык: Английский
Enhancement of photocatalytic oxidation by water-driven piezoelectricity using MoO3/P(VDF-TrFE) mixed matrix membranes
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Год журнала:
2024,
Номер
688, С. 133620 - 133620
Опубликована: Март 2, 2024
Язык: Английский
Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(18), С. 13367 - 13372
Опубликована: Сен. 6, 2024
An
efficient
method
for
the
preparation
of
difluoromethylated
benzothiophenes
via
visible-light-mediated
alkyne
difunctionalization
was
developed.
In
this
method,
inexpensive
sodium
difluoromethanesulfinate
(HCF
Язык: Английский
Developments in the Construction of Benzo[b]thiophenes from 2‐Alkynylthioanisoles by Electrophilic and Radical Cyclization Reactions
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
Benzo[
b
]thiophene
moieties
are
important
skeletons
which
have
been
widely
found
in
many
natural
products,
pharmaceuticals,
as
well
functionalized
materials.
2‐Alkynylthioanisoles,
a
class
of
bifunctional
compounds
bearing
methylthio
and
alkynyl
groups,
easily
accessible
from
Pd‐catalyzed
Sonogashira
coupling
between
2‐halothioanisoles
terminal
alkynes,
employed
synthons
the
construction
benzo[b]thiophenes
through
an
electrophilic
or
radical
pathway.
This
review
summarizes
related
developments
with
particular
focus
on
reaction
mechanism.
We
hope
it
will
help
future
research
this
area
believe
that
discovery
new
catalytic
systems,
industrial
synthesis
benzo[
]thiophenes
2‐alkynylthioanisoles
be
achieved
soon.
Язык: Английский