Ruthenium–Hydride Complexes Facilitated Sustainable Synthesis of Isoxazolones via Acceptorless Dehydrogenative Annulation of Alcohols
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
streamlined
strategy
for
the
one-pot
synthesis
of
isoxazolone
analogues
has
been
developed
through
an
acceptorless
dehydrogenative
annulation
(ADA)
pathway
by
employing
new
Ru(II)
hydride
complexes
as
effective
catalysts.
New
(C1–C3)
tailored
with
N̂O
chelating
carbazolone
benzhydrazone
ligands
were
synthesized
and
their
formation
was
confirmed
using
analytical
spectral
techniques
including
FT-IR
NMR.
The
structural
configuration
featuring
octahedral
geometry
around
ion
precisely
determined
single-crystal
X-ray
diffraction
analysis.
Further,
catalytic
efficacy
titled
established
facile
productive
derivatives
from
a
diverse
range
benzyl
alcohols,
methyl
acetoacetate/ethyl
benzoylacetate
hydroxylamine
hydrochloride,
generating
excellent
yields
up
to
93%
under
well-suited
mild
conditions
1
mol
%
catalyst
loading.
sequence
time-dependent
control
experiments
unveiled
ADA
route,
indicating
initial
generation
4-methoxy
benzaldehyde
intermediate
followed
3-phenylisoxazol-5(4H)-one,
accompanied
release
water
hydrogen
byproducts.
Gram-scale
compound
indicates
industrial
relevance
our
synthetic
strategy.
short
medicinally
active
androgen
antagonist
illustrates
utility
present
protocol.
Язык: Английский
Cumgmn Layered Double Hydroxide Acts as a Multifunctional Catalyst for the Efficient Synthesis of Quinolines Through Cascade Reactions
Опубликована: Янв. 1, 2025
Язык: Английский
Syntheses of 2,4‐Substituted Quinazolines via One‐Pot Three‐Component Reactions Based on Manganese Dioxide/tert‐Butyl Hydrogen Peroxide Co‐Oxidation Using Alcohols
Journal of Heterocyclic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 25, 2024
ABSTRACT
Quinazolines
and
their
derivatives
occur
in
various
natural
products
pharmaceuticals,
thus,
methods
of
synthesizing
quinazolines
have
been
explored.
They
traditionally
synthesized
via
two‐component
reactions,
but
these
strategies
often
suffer
from
the
unavailability
starting
materials
limited
substrate
scopes.
To
overcome
problems,
three‐component
reactions
using
additional
N
sources
were
developed.
Aldehydes
initially
used
alcohols
are
greener
less
toxic
than
aldehydes.
However,
previously
reported
involving
use
require
utilization
transition
metal
catalysts,
ultrahigh
temperatures,
extended
durations.
Thus,
an
efficient,
practical
method
alcohol
is
desirable.
A
facile
one‐pot
utilizing
alcohols,
2‐aminobenzoketones,
ammonium
acetate
for
first
time,
active
MnO
2
tert
‐butyl
hydrogen
peroxide
(TBHP)
as
synergistic
oxidants.
TBHP
play
dual
roles:
First,
they
oxidize
to
aldehyde
then
facilitate
transformation
intermediate
into
product.
During
oxidation,
effect
particularly
evident.
The
aldehydes
generated
situ
oxidation
undergo
immediate
subsequent
thereby
minimizing
volatilization
side
such
polymerization.
Язык: Английский
A TEMPO promoted tandem reaction of 2-aminobenzophenones and benzylamines under electrochemical conditions
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(10), С. 1983 - 1987
Опубликована: Янв. 1, 2024
This
study
describes
the
efficient
synthesis
of
quinazolines
promoted
by
TEMPO
via
electro-catalysis
with
2-aminobenzophenones
and
benzylamines.
Язык: Английский
NNO Pincer-Supported Pd(II)-Catalyzed Reductive N-Alkylation of Challenging Nitroarenes with Alcohols via Borrowing Hydrogen Strategy
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(16), С. 11161 - 11172
Опубликована: Июль 31, 2024
A
sustainable
catalytic
synthesis
of
selective
monoalkylated
amines
from
nitroarenes
and
alcohols
by
new
palladium(II)-NNO
pincer-type
complexes
has
been
described.
Herein,
a
series
Pd(II)
[Pd(NNO)PPh
Язык: Английский
Six-membered ring systems: Diazines and benzo derivatives
Progress in heterocyclic chemistry,
Год журнала:
2024,
Номер
unknown, С. 355 - 393
Опубликована: Янв. 1, 2024
Electrochemical Synthesis of Quinazolines: N–H/C(sp3)–H Coupling of o-Carbonyl Anilines with Amino Acids and Amines
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
A
mild
and
efficient
electrochemical
protocol
for
the
synthesis
of
quinazolines
through
N-H/C(sp
Язык: Английский
Synthesis and structure of binuclear arene Ru(ii) N^O chelating complexes: synthesis of pyrimidinones via acceptorless dehydrogenative annulation using alcohols
New Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
Binuclear
arene
Ru(
ii
)
hydrazine
complexes
catalysed
eco-friendly,
selective
and
sustainable
synthesis
of
bioactive
pyrimidinones
via
acceptorless
dehydrogenative
annulation
alcohols.
Язык: Английский