In Silico Characterization of Indole-Substituted Densely Functionalized Pyrrole Against Breast Cancer: Integrating DFT, Molecular Docking, MD Simulations, and ADME Analysis

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141375 - 141375

Опубликована: Янв. 1, 2025

Язык: Английский

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Synthesis of Tetrasubstituted Pyrroles via DBU-Mediated Cyclization of Unactivated Propargyl Tertiary Amines

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Compared with the well-developed cyclization of functionalized propargylamines, use unactivated tertiary propargylamines to access pyrroles remains challenging. Herein, we report an efficient method for constructing tetrasubstituted via a DBU-mediated intramolecular cycloaddition N-alkyl propargylamines. This reaction employs dihydropyrrole intermediates, followed by oxidation produce in presence 2,3-dichloro-5,6-dicyano-p-benzoquinone. In addition, broad substrate scope, high atom economy, selectivity, and simple operation are also advantages this protocol.

Язык: Английский

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Guanidine Hydrochloride (GuHCl) Catalysed Microwave-Mediated Solvent- and Metal-Free Synthesis of Pyrimido[1,2-a]benzimidazole from Aryl Aldehyde and Aryl Methyl Ketone

Green Chemistry, Год журнала: 2024, Номер 26(16), С. 9230 - 9240

Опубликована: Янв. 1, 2024

The rapid, eco-friendly, solvent- and metal-free microwave-assisted synthesis of pyrimido[1,2- a ]benzimidazole in high yields was achieved using the green organocatalyst guanidine hydrochloride simple inexpensive starting materials.

Язык: Английский

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Protein profiling uncovers IGF-1R inhibition potential of 3-(2-furoyl)-indole scaffolds in hepatocellular carcinoma

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Март 3, 2025

Aim This study investigates the anti-proliferative potential and possible molecular mechanisms of 3-(2-furoyl)-indole derivatives against HepG2.

Язык: Английский

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Indium(III)-Catalyzed Synthesis of Pyrroles and Benzo[g]indoles by Intramolecular Cyclization of Homopropargyl Azides

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 16015 - 16021

Опубликована: Окт. 15, 2024

Pyrroles, privileged structural motifs in drug and material science, have been synthesized by indium(III)-catalyzed intramolecular cyclization of homopropargyl azides. This methodology exhibits a broad substrate scope, providing substituted pyrroles bispyrroles good yields. Furthermore, an atom-economical sequential method for the synthesis benzo[

Язык: Английский

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Easy one-pot synthesis of multifunctionalized indole–pyrrole hybrids as a new class of antileishmanial agents

RSC Advances, Год журнала: 2024, Номер 14(22), С. 15713 - 15720

Опубликована: Янв. 1, 2024

A chemoselective one-pot synthesis of indole–pyrrole hybrids has been developed. The new were phenotypically screened for efficacy against L. infantum promastigotes. Compound 3d was the most active with IC 50 = 9.6 μM and a selectivity index 5.

Язык: Английский

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A novel nanoplastic removal method based on solar interface evaporation technology

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 154290 - 154290

Опубликована: Июль 26, 2024

Язык: Английский

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