Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
We report the reactivity of in situ-generated nucleophilic siloxycarbenes from acylsilanes via 1,2-Brook rearrangement presence visible light with heterocumulenes. This method significantly advances conventional use electrophilic carbenes stabilized by metal catalysts and harsh reaction conditions. The was explored isocyanates, carbodiimides,
Язык: Английский
Industrial Crops and Products, Год журнала: 2024, Номер 222, С. 119738 - 119738
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
4
Russian Chemical Bulletin, Год журнала: 2025, Номер 74(1), С. 137 - 142
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Abstract α ‐Ketoamides are privileged chemical entities featuring a carbonyl group bonded to an amide. Bearing two pronucleophilic and proelectrophilic sites, this structural scaffold exhibits distinct properties unparalleled biological activity. Owing its wide application in medicinal, agricultural, synthetic chemistry, methods for assembling moiety ever‐growing demand. With the increasing focus on green synthesis, traditional routes ‐ketoamides have faded recent years giving rise development of photocatalytic, electrosynthetic, microwave‐assisted catalytic protocols. We hereby provide comprehensive critical summary all advancements witnessed field from 2016 present.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(11), С. 8137 - 8145
Опубликована: Май 17, 2024
We have introduced a sulfoximidation reaction initiated by visible light between α-phenyl vinyl azides and NH-sulfoximines. The cost-effective readily accessible hypervalent iodine reagent (PIDA) easily promoted the oxidative process to afford N-α-ketoacylated sulfoximines in good high yields, involving formation of two new C–O bonds one C–N bond. Additionally, protocol offers noteworthy advantages, including its metal-free photocatalyst-free broad substrate compatibility.
Язык: Английский
Процитировано
2
Synthesis, Год журнала: 2024, Номер 56(17), С. 2627 - 2637
Опубликована: Апрель 2, 2024
Abstract Pnictogens, classified within group 15 elements, play a pivotal role in the constitution of diverse array drug molecules, natural products, and functional materials. Recent research has increasingly prioritized exploration mild conditions for synthesizing C–Pnictogen (C–N C–P) bonds, highlighting growing emphasis on efficient sustainable synthetic methodologies. This Short Review explores fundamental mechanisms, addresses constraints, assesses methodologies, underscoring potential photocatalyst- transition-metal-free photochemical reactions advancing sustainability. Divided into two segments, it encompasses recent advancements facilitating C–N C–P bond formation. 1 Introduction 2 Carbon–Nitrogen (C–N) Bond Formation 3 Carbon–Phosphorus (C–P) 4 Summary Outlook
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 10, 2024
Precisely controlling the product selectivity of a reaction is an important objective in organic synthesis. α-Ketoamides are vital intermediates chemical transformations and privileged motifs numerous drugs, natural products, biologically active molecules. The selective synthesis α-ketoamides from feedstock chemicals safe operationally simple manner under mild conditions long-standing catalysis challenge. Herein, unprecedented TBD-switched Pd-catalyzed double isocyanide insertion for assembling ketoamides aqueous DMSO (hetero)aryl halides pseudohalides reported. effectiveness utility this protocol demonstrated by its diverse substrate scope (93 examples), ability to late-stage modify pharmaceuticals, scalability large-scale synthesis, pharmaceutically Mechanistic studies indicate that TBD key ligand modulates process, thereby selectively providing desired unique manner. In addition, imidoylpalladium(II) complex α-ketoimine amide successfully isolated determined X-ray analysis, confirming they probable catalytic pathway.
Язык: Английский
Процитировано
1
Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(33), С. 6708 - 6712
Опубликована: Янв. 1, 2024
An efficient method for the construction of an array α-ketoamides has been described from readily available O -benzoyl hydroxylamines and diazo compounds as starting materials by combined use CuI a catalyst H 2 oxygen source.
Язык: Английский
Процитировано
1
Synlett, Год журнала: 2024, Номер unknown
Опубликована: Июль 30, 2024
Abstract Thiuram disulfides undergo a Cu(I)-catalyzed C–S cross-coupling with aryl iodides through Cu(OAc)2·H2O-assisted desulfurization to produce the S-thiocarbamate ester compounds efficiently. Various containing diverse substituents underwent smooth reaction series of cyclic and acyclic secondary amine-based thiuram under an open-air atmosphere. A probable mechanistic pathway has been suggested based on control experiments reports from literature.
Язык: Английский
Процитировано
0
Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140434 - 140434
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
We report the reactivity of in situ-generated nucleophilic siloxycarbenes from acylsilanes via 1,2-Brook rearrangement presence visible light with heterocumulenes. This method significantly advances conventional use electrophilic carbenes stabilized by metal catalysts and harsh reaction conditions. The was explored isocyanates, carbodiimides,
Язык: Английский
Процитировано
0