Amination of Phenols and Halophenols via Pyridinium–Iridium Dual Photocatalysis DOI Creative Commons
Matthew C. Carson, C. Liu, Yaning Liu

и другие.

Опубликована: Апрель 12, 2024

In this study, we present a photochemical method for the amination of phenols (C–H) and halophenols (SNAr), facilitated by dual catalytic pathways involving both Ir(III) photocatalysis phenol–pyridinium EDA complexation. By incorporating pyridinium additive, achieved efficient C–N coupling between diverse aromatic nitrogen nucleophiles, delivering high yields (up to 99%) across wide range substrates, including pharmaceuticals natural products. We investigate reaction selectivity substrate compatibility/limitations through combination experimental computational techniques. Moreover, highlight synthetic versatility products various late-stage functionalizations grafting two different heteroarenes onto one phenol scaffold.

Язык: Английский

Amination of Phenols and Halophenols via Pyridinium–Iridium Dual Photocatalysis DOI
Matthew C. Carson, C. Liu,

Yaning Liu

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(16), С. 12173 - 12180

Опубликована: Июль 30, 2024

In this study, we present a photochemical method for the amination of phenols (C–H) and halophenols (SNAr), facilitated by dual catalytic pathways involving both Ir(III) photocatalysis phenol–pyridinium electron donor–acceptor complexation. By incorporating pyridinium additive, achieved efficient C–N coupling between diverse aromatic nitrogen nucleophiles, delivering high yields (up to 99%) across wide range substrates, including pharmaceuticals natural products. We investigate reaction selectivity substrate compatibility/limitations through combination experimental computational techniques. Moreover, highlight synthetic versatility products various late-stage functionalizations grafting two different heteroarenes onto one phenol scaffold.

Язык: Английский

Процитировано

4
Amination of Phenols and Halophenols via Pyridinium–Iridium Dual Photocatalysis DOI Creative Commons
Matthew C. Carson, C. Liu, Yaning Liu

и другие.

Опубликована: Апрель 12, 2024

In this study, we present a photochemical method for the amination of phenols (C–H) and halophenols (SNAr), facilitated by dual catalytic pathways involving both Ir(III) photocatalysis phenol–pyridinium EDA complexation. By incorporating pyridinium additive, achieved efficient C–N coupling between diverse aromatic nitrogen nucleophiles, delivering high yields (up to 99%) across wide range substrates, including pharmaceuticals natural products. We investigate reaction selectivity substrate compatibility/limitations through combination experimental computational techniques. Moreover, highlight synthetic versatility products various late-stage functionalizations grafting two different heteroarenes onto one phenol scaffold.

Язык: Английский

Процитировано

2