Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139870 - 139870
Опубликована: Сен. 1, 2024
Язык: Английский
Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139870 - 139870
Опубликована: Сен. 1, 2024
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
A base-promoted regioselective formal [3 + 2] annulation of pyridinium ylides with bromoalkynes is reported, producing a series substituent-diverse indolizines in generally good yields. mild K2CO3-promoted three-component cyclization and at 2:1 molar ratio delivered C2-acylmethylated indolizines, whereas C2-brominated were generated starting from bearing strong electron-withdrawing groups the unit by using 2,2,6,6-tetramethyl-1-piperidinyloxy as dehydrogenating reagent. The current synthetic methodology offers controllable modular approach to access different substitution patterns, featuring wide substrate scope, functional group compatibility, complete regioselectivity without demand any transition-metal catalysts.
Язык: Английский
Процитировано
1The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
N-Iodosuccinimide-promoted cascade reactions of arylidene isoxazolones with amidines in p-xylene were accomplished, affording 5-acylimidazoles good to excellent yields. Interestingly, when the performed by employing acetonitrile as solvent, 4-acylimidazoles efficiently obtained. Mechanistic studies indicate that formation imidazolyl and acyl moieties may undergo a spiroannulation-ring opening aromatization-hydrolysis reaction sequence. Based on this solvent-regulated tandem strategy, powerful protocol for switchable regiodivergent synthesis structurally diverse was successfully established.
Язык: Английский
Процитировано
0The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 19, 2025
A straightforward and efficient strategy for the synthesis of fully functionalized indolizines has been developed through a transition metal- oxidant-free [3 + 2] cycloaddition reaction zwitterionic ketenimines pyridinium salts. This versatile method proceeds under mild conditions, affording in moderate to good yields. approach involves an intermolecular cycloaddition, followed by enamine/imine tautomerization aromatization. Notably, this demonstrates broad functional group compatibility allows facile scalability, making it valuable tool indolizine-based frameworks organic medicinal chemistry.
Язык: Английский
Процитировано
0Molecules, Год журнала: 2024, Номер 29(8), С. 1701 - 1701
Опубликована: Апрель 9, 2024
An attractive approach for the preparation of spirocyclic benzofuran–furocoumarins has been developed through iodine-catalyzed cascade annulation 4-hydroxycoumarins with aurones. The reaction involves Michael addition, iodination, and intramolecular nucleophilic substitution in a one-step process, offers an efficient method easy access to series valuable good yields (up 99%) excellent stereoselectivity. Moreover, this unprecedented protocol provides several advantages, including readily available materials, environmentally benign catalyst, broad substrate scope, simple procedure.
Язык: Английский
Процитировано
0Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139870 - 139870
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0