Construction of Diverse Fused Chromene Frameworks via Isocyanide-Based Three-Component Reaction

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10854 - 10866

Опубликована: Июль 12, 2024

A convenient synthetic protocol for diverse fused chromenes was successfully developed by a three-component reaction of alkyl isocyanides, dialkyl but-2-ynedioates, and various cyclic 1,3-dipolarophiles containing

Язык: Английский

Interrupted Barton–Zard Reaction/Friedel–Crafts Alkylation Telescoped Reaction for the Synthesis of Pyrrolo[3,4‐b]indole Cores

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

Abstract A dearomatization reaction between electron‐deficient indoles and α,α‐diaryl‐substituted methyleneisocyanides, followed by in situ Friedel–Crafts alkylation, is described. In a telescoped mediated Brønsted base the first step acid second step, aryl‐substituted pyrrolo[3,4‐b]indole cores are generally obtained moderate‐to‐good yields with high diastereoselectivity. The tolerates wide range of 3‐nitroindoles aryl nucleophiles; however, substrate scope isocyanide derivatives limited. developed methodology offers modular approach for synthesis multi‐substituted polycyclic cores.

Язык: Английский

Progresses in the Preparation of Chromone Compounds and Their Applications in Organic Synthesis

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(11), С. 3345 - 3345

Опубликована: Янв. 1, 2024

Язык: Английский