Cascade approach to synthesize BIMs and analogues in different nucleophilic conditions

Tetrahedron Letters, Год журнала: 2024, Номер 148, С. 155248 - 155248

Опубликована: Авг. 11, 2024

Язык: Английский

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Direct α,β-C–H Difunctionalization of Piperidines for the Construction of the N,O-Acetal Skeleton via 1,5-Hydride Transfer

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 13373 - 13385

Опубликована: Сен. 5, 2024

Herein, we describe an unprecedented Lewis acid-catalyzed annulation of phenols with

Язык: Английский

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Diaryliodonium Salt‐Mediated Radical Transformation of Indoles with Alcohols for the Synthesis of Unsymmetrical Bis(indolyl)methanes

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 10, 2024

Abstract A method for the synthesis of unsymmetrical bis(indolyl)methanes (BIMs) using simple indoles and readily available alcohols as coupling partners under both heat 390–400 nm light conditions was developed. Detailed research mechanism demonstrated that diaryliodonium salt‐mediated transformation undergoes a nucleophilic hydroxymethyl radical formation process. Moreover, is also applicable synthesizing symmetrical BIMs.

Язык: Английский

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Molecular-Oxygen-Mediated Multicomponent Oxidative Cyclization: Synthesis of Tertiary-Alcohol-Unit-Bearing N-Heterocycles via Transforming C–H to C–OH Bonds

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

We developed a molecular-oxygen-mediated multicomponent oxidative cyclization strategy to synthesize N-heterocycles containing tertiary alcohol units via the formation of key C–OH bonds and quaternary carbon centers. This formal [3 + 2 1] annulation offers green sustainable alternative for de novo bond formation, using O2 as both oxidant oxygen source under metal- catalyst-free conditions. Notably, continuous [1,5]-hydrogen transfer together with excess alcohols promotes C–OH-bearing products. Additionally, generation centers inhibits conversion C═O bonds, thus stabilizing desired

Язык: Английский

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Synthesis, Characterization and Biological Evaluation of 3‐Oxo‐pyrimido[1,2‐b]indazoles

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(19), С. 4055 - 4060

Опубликована: Июль 20, 2024

Abstract The synthesis of substituted 3‐oxo‐pyrimido[1,2‐ b ]indazoles from 3‐aminoindazoles and ketones has been established. It involves one molecule two molecules via a [3+2+1] three‐component annulation process. 3‐Oxo‐pyrimido[1,2‐b]indazoles exhibit strong yellow fluorescence in various solvents. A wide range products have anti‐oxidant activities. Cytotoxicity studies indicate that compounds 3 , aa ab obvious effects on both HCT116 A549 cancer cell lines.

Язык: Английский

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Recent Advances in Diazophosphonate Chemistry: Reactions and Transformations

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Сен. 5, 2024

Abstract Diazophosphonates function as indispensable synthetic intermediates within the domain of organic chemistry, serving precursors for a diverse range molecules, with potential applications bioactive compounds. α-Diazomethylphosphonates showcase expansive reactivity and elevated levels enantioselectivity in asymmetric transformations, especially conjunction suitable catalyst systems. This review compiles latest advancements diazophosphonate chemistry from 2016 to 2024, highlighting their transformative synthesis. Diazophosphonates, regarded revolutionary compounds, exhibit unique attributes carbene precursors, driving chemical reactions such [3+2] cycloaddition, [3+3] substitution reactions. Their adaptability functional group conversions underscores pivotal role various methodologies. The highlights growing interest among chemists, fostering novel strategies expanding application horizons. multifaceted utility diazophosphonates reagents, intermediates, catalysts significance modern pharmaceutical applications, prompting further exploration into this dynamic field. 1 Introduction 2 Cycloaddition Reactions 3 Asymmetric 4 5 Substitution 6 Carbene Precursors 7 Chemistry Fluorinated Compounds 8 Other 9 Future Directions 10 Conclusion

Язык: Английский

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Strategies Employing Transition‐Metal Free Conditions for C−C Bond Formation in Indoles

ChemistrySelect, Год журнала: 2024, Номер 9(36)

Опубликована: Сен. 19, 2024

Abstract Indole motifs are omnipresent in nature and can be found many natural products as well pharmaceuticals. It is for this reason synthetic transformations of indole have become a topic interest the organic medicinal chemist community decades. In review, we emphasized functionalization indoles via transition‐metal‐free approaches. This review touches on aspects different sub‐sections, which gives proposition tactics employed an overview road ahead.

Язык: Английский

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Reductive synthesis of azoxypyridines from nitropyridines using hydroxides in alcoholic media

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Abstract The partial reduction of nitroarenes with hydroxides in alcoholic media is a venerable yet very direct approach to the synthesis symmetrical azoxyarenes. Herein, first application this method nitropyridines disclosed, presenting its adaptation these challenging but important substrates.

Язык: Английский

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Construction of 3,5-Diarylpyridine Derivatives Using N,N-Dimethyl-ethanolamine as a Single-Carbon Synthon

Chinese Journal of Organic Chemistry, Год журнала: 2024, Номер 44(11), С. 3409 - 3409

Опубликована: Янв. 1, 2024

Язык: Английский

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