Electrochemical Enaminone-Thioamide Annulation and Thioamide Dimeric Annulation for the Tunable Synthesis of Thiazoles and 1,2,4-Thiadiazole
Organic Letters,
Год журнала:
2024,
Номер
26(25), С. 5263 - 5268
Опубликована: Июнь 14, 2024
A
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
thioamides
under
metal-
oxidant-free
conditions
has
been
developed,
providing
an
efficient
approach
for
thiazole
synthesis.
Furthermore,
1,2,4-thiadiazoles
can
be
selectively
accessed
via
the
dimerization
in
absence
enaminones.
Язык: Английский
Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds
RSC Advances,
Год журнала:
2025,
Номер
15(2), С. 1447 - 1489
Опубликована: Янв. 1, 2025
We
have
reviewed
the
recently
reported
multicomponent
reactions
(MCRs)
yielding
cyclic
frameworks
in
a
single
pot
from
simple
building
blocks
under
mild
conditions.
These
MCRs
may
prove
to
be
useful
for
drug
discovery
projects.
Язык: Английский
Photocatalytic Annulation of Enaminones with Thioureas for the Synthesis of 2-Aminothiazoles via Tandem C–S and C–N Bond Formation
Synthesis,
Год журнала:
2024,
Номер
56(16), С. 2565 - 2571
Опубликована: Апрель 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
Язык: Английский
One-Pot Multicomponent Synthesis of Fully Substituted 1,3-Thiazoles Appended with Naturally Occurring Lawsone
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Lawsone
is
a
popular
bioactive
natural
product.
1,3-Thiazoles
are
also
widely
distributed
in
many
products,
FDA-approved
drugs,
and
functional
materials.
We
report
herein
the
first
synthesis
of
naturally
occurring
lawsone-linked
fully
substituted
1,3-thiazoles
one-pot
multicomponent
reaction
(MCR)
arylglyoxals,
lawsone,
thiobenzamides
acetic
acid
at
90
°C,
affording
lawsone-1,3-thiazole
hybrids
excellent
yields
short
times.
The
advantages
present
method
include
facile,
robust,
easy
access
to
medicinally
relevant
diverse
array
hybrids,
isolation
product
by
filtration,
thereby
avoiding
column-chromatographic
purifications,
time,
metal-
catalyst-free
gram-scale
synthesis.
Язык: Английский
Synthesis of indole-linked β-cyano-enones: a pathway to indolyl-2-pyrrolones
Nurabul Mondal,
Vidya Kumari,
Danish Ali
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
multicomponent
reaction
of
arylglyoxal,
malononitrile,
and
indoles
in
DMF
yields
indole-linked
β-cyano-enones,
which
serve
as
precursors
for
medicinally
relevant
2-pyrrolones,
1,2-diketones,
quinoxalines.
Язык: Английский
Green synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives using sulfonic acid-supported magnetic covalent organic framework as a novel and reusable nanostructured catalyst
Research on Chemical Intermediates,
Год журнала:
2024,
Номер
50(9), С. 4229 - 4247
Опубликована: Июль 26, 2024
Язык: Английский
Synthesis of Highly Fluorescent Thiazole Fused Benzo[a] Carbazoles by Sunlight Driven Photocyclization of Indolylthiazoles
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Herein
we
report
for
the
first
time
a
sunlight‐driven,
irreversible
photocyclization
reaction
of
indole‐linked
trisubstituted
thiazoles,
synthesis
highly
fluorescent
thiazole‐fused
benzo[
]carbazoles
using
mixture
solvents
(CH
3
CN:
DMSO;
:
1).
Ring
opening
indole
moiety
was
observed
in
case
thiazole
derivatives
having
2‐methyl
substituents.
Under
similar
conditions,
thiazoles
cyclic
1,3‐dicarbonyls
place
also
worked.
This
provides
products
two
medicinally
important
moieties
and
benzocarbazoles.
We
have
studied
photophysical
properties
all
found
that
most
synthesized
very
good
fluorescence
quantum
yields.
Язык: Английский
Multicomponent Synthesis of New Fluorescent Boron Complexes Derived from 3-Hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde
Molecules,
Год журнала:
2024,
Номер
29(14), С. 3432 - 3432
Опубликована: Июль 22, 2024
Novel
fluorescent
pyrazole-containing
boron
(III)
complexes
were
synthesized
employing
a
one-pot
three-component
reaction
of
3-hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde,
2-aminobenzenecarboxylic
acids,
and
boronic
acids.
The
structures
the
novel
heterocyclic
compounds
confirmed
using
1H-,
13C-,
15N-,
19F-,
11B-NMR,
IR
spectroscopy,
HRMS,
single-crystal
X-ray
diffraction
data.
photophysical
properties
obtained
iminoboronates
investigated
spectroscopic
techniques,
such
as
UV–vis
fluorescence
spectroscopies.
Compounds
display
main
absorption
maxima
in
blue
region,
emission
are
observed
green
region
visible
spectrum.
It
was
revealed
that
exhibit
quantum
yield
up
to
4.3%
different
solvents
demonstrate
an
aggregation-induced
enhancement
effect
mixed
THF–water
solutions.
Язык: Английский
Visible Light‐Mediated Multicomponent Synthesis of Spirooxindole‐Linked Fused Pyrans: An Eco‐Friendly One‐Pot Strategy
Nurabul Mondal,
Darshika Singh,
Vidya Kumari
и другие.
ChemistrySelect,
Год журнала:
2024,
Номер
9(37)
Опубликована: Окт. 2, 2024
Abstract
A
green
and
efficient
method
for
the
preparation
of
spirooxindole‐linked
fused
pyrans
has
been
developed
utilizing
a
catalyst‐free
visible‐light‐driven
one‐pot
multicomponent
reaction
strategy.
The
was
performed
in
water
ethanol
mixture,
using
combination
isatin,
malononitrile,
cyclic
1,3‐dicarbonyls
such
as
4‐hydroxy‐1‐methyl‐2(1
H
)‐quinolone,
4‐hydroxycoumarin,
4‐hydroxythiocoumarin,
or
barbituric
acid
derivatives.
This
catalyst‐free,
environmentally
friendly,
visible‐light‐driven,
room
temperature
is
valuable
addition
to
synthetic
toolbox
constructing
complex
heterocyclic
scaffolds
under
conditions.
It
holds
promise
future
applications
medicinal
chemistry
drug
discovery.
Язык: Английский
Catalytic Potential of Fluorescein under Visible Light Irradiation: Enabling Single-Pot Open Flask Synthesis of Novel Pyrazolyl Methanesulfonamides
Journal of Organometallic Chemistry,
Год журнала:
2024,
Номер
1025, С. 123476 - 123476
Опубликована: Дек. 11, 2024
Язык: Английский