Iron-Catalyzed Thioarylation of Arenes Using Saccharin-Derived Reagents

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Biaryl sulfides are important scaffolds found in various natural products and pharmaceutically active compounds. One of the main approaches for synthesis this compound class involves substitution arenes using electrophilic thioaryl species. However, these methods generally require acidic activation electrophile, more forcing conditions, long reaction times. Here, we describe combination super Lewis acid iron(III) triflimide with saccharin-based thioarylation reagents rapid unsymmetrical biaryl under mild conditions. This approach was effective electron-deficient species that performed poorly previous methods, allowing efficient functionalization bioactive

Язык: Английский

Recent Advances in (Di)Azafluorene Chemistry (A Review)

Russian Journal of Organic Chemistry, Год журнала: 2024, Номер 60(11), С. 2086 - 2107

Опубликована: Ноя. 1, 2024

Язык: Английский