Alcohols as Alkyl Synthons Enabled by Photoredox-Catalyzed Deoxygenative Activation

ACS Catalysis, Год журнала: 2024, Номер 14(17), С. 13451 - 13496

Опубликована: Авг. 26, 2024

Alcohols are abundant with versatile structural variety and have ample use as pivotal functional groups in numerous organic processes. Because of their frequent occurrence enumerable natural products, bioactive molecules, medicinal components, alcohol functionalities provide a promising scope research to advance the operational diversity for improving clinical success. Recent years witnessed design modern C–C C–heteroatom bond-forming approaches easily accessible commercially available unactivated aliphatic alcohols native adaptive sp3 handles, hence offering groundbreaking transformative pathways functionalization complex molecular architectures. The judicial application appropriate activating generate alkyl radical from through C–O bond fragmentation employ it potential alkylating agent unfolds unique synthetic strategies, thereby replacing obvious requirement halides. This review elaborately discusses recent trends regarding using C(sp3)-centered various chemical transformations by exploiting different activation modes disrupter under photoredox catalysis. presentation is organized nature scaffolds, kind formation, progress achieved this domain since original discovery providing illustrative examples mechanistic details, focus on difficulties future prospects.

Язык: Английский

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Visible-Light-Promoted Deoxygenative Alkylation of Quinoxalin-2(1H)-ones with Activated Alcohols

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(9), С. 6334 - 6344

Опубликована: Апрель 15, 2024

A one-pot strategy for deoxygenative alkylation of alcohols with quinoxalin-2(1H)-ones was developed by using xanthate salts as alcohol-activating groups radical generation in the presence tricyclohexylphosphine under visible-light-promoted conditions. The remarkable features this reaction include a broad substrate scope, excellent functional group tolerance, mild conditions, and simple operation. Moreover, synthetic utility validated success two-step reactions, scale-up synthesis, chemoselective monodeoxygenation diols.

Язык: Английский

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Copper‐Catalyzed Cascade Phosphorodithiolation/Cyclization of β‐Ketodinitriles: Organic Transformation of P₄S₁₀

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Comprehensive Summary An innovative approach to synthesizing pyrrole‐functionalized phosphorodithioates via a copper‐catalyzed cascade phosphorodithiolation/cyclization of β‐ketodinitriles is disclosed. This method employs tetraphosphorus decasulfide (P 4 S 10 ) as phosphorus source, activated by alcohols under mild conditions. A wide range and are well‐tolerated, affording the desired products with good excellent yields, underscoring broad functional group compatibility. Notably, this process eschews need for noble metal catalysts, aligning green chemistry principles enabling direct sustainable transformation from inorganic organic phosphorus. Furthermore, synthesized demonstrate potent antibacterial properties against Staphylococcus aureus .

Язык: Английский

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Self-assembly of decavanadate and Ni(HCO3)2 into nanoparticles anchored on carbon nitride for efficient photocatalytic Minisci-type alkylation

Journal of Catalysis, Год журнала: 2024, Номер unknown, С. 115789 - 115789

Опубликована: Окт. 1, 2024

Язык: Английский

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