Journal of Molecular Structure, Год журнала: 2024, Номер 1323, С. 140621 - 140621
Опубликована: Ноя. 10, 2024
Язык: Английский
Journal of Molecular Structure, Год журнала: 2024, Номер 1323, С. 140621 - 140621
Опубликована: Ноя. 10, 2024
Язык: Английский
ACS Catalysis, Год журнала: 2024, Номер 14(16), С. 12173 - 12180
Опубликована: Июль 30, 2024
In this study, we present a photochemical method for the amination of phenols (C–H) and halophenols (SNAr), facilitated by dual catalytic pathways involving both Ir(III) photocatalysis phenol–pyridinium electron donor–acceptor complexation. By incorporating pyridinium additive, achieved efficient C–N coupling between diverse aromatic nitrogen nucleophiles, delivering high yields (up to 99%) across wide range substrates, including pharmaceuticals natural products. We investigate reaction selectivity substrate compatibility/limitations through combination experimental computational techniques. Moreover, highlight synthetic versatility products various late-stage functionalizations grafting two different heteroarenes onto one phenol scaffold.
Язык: Английский
Процитировано
5Scientific Data, Год журнала: 2024, Номер 11(1)
Опубликована: Авг. 10, 2024
Iridium(III) complexes nowadays became rising stars in various health-related applications. Thus, there is a necessity to assess cytotoxicity of the synthesized molecules against cancer/normal cell lines. In this report, we present dataset 2694 experimental values 803 iridium 127 different We specify conditions and provide representation machine-readable format. The provides starting point for exploration new iridium-based cellular probes opens possibilities predictions toxicities data-driven generation organometallic anticancer agents.
Язык: Английский
Процитировано
4The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Thianthrenium salts have emerged as one of the most versatile reagents, gaining significant popularity within synthetic community for their utility in construction C-C and C-X (X = N, O, S, P, halogens) bonds. The use photoredox transition metal catalysis with thianthrenium C-heteroatom bond formation is well established. However, these methods require elevated temperatures, expensive catalysts, ligands under stringent conditions effective execution. In contrast, photocatalysis- transition-metal-free approaches constructing bonds using salt derivatives become increasingly sought after. this regard, electron-donor-acceptor (EDA)-complex reactions a powerful strategy organic synthesis, eliminating need photocatalysts visible light irradiation. EDA-complex photochemistry exploits electron-acceptor properties salts, facilitating rapid generation radical intermediates via C-S cleavage. These play pivotal role enabling variety valuable formations. Perspective, we highlight advances EDA-complex-mediated involving mechanisms, substrate scope, limitations For sake brevity, article organized into five main sections: (1) Nitrogen-based donor reactions, (2) Oxygen-based (3) Sulfur-based (4) Phosphorus-based (5) π-based focus on C-C, C-S, C-B C-P
Язык: Английский
Процитировано
0Опубликована: Апрель 12, 2024
In this study, we present a photochemical method for the amination of phenols (C–H) and halophenols (SNAr), facilitated by dual catalytic pathways involving both Ir(III) photocatalysis phenol–pyridinium EDA complexation. By incorporating pyridinium additive, achieved efficient C–N coupling between diverse aromatic nitrogen nucleophiles, delivering high yields (up to 99%) across wide range substrates, including pharmaceuticals natural products. We investigate reaction selectivity substrate compatibility/limitations through combination experimental computational techniques. Moreover, highlight synthetic versatility products various late-stage functionalizations grafting two different heteroarenes onto one phenol scaffold.
Язык: Английский
Процитировано
2Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Herein, we present an efficient Cu( ii )-catalyzed cascade synthesis of sulfonated 3-carboxamide quinolin-2-(1 H )-ones. Inthis paper, sulfonylhydrazides underwent unusual N–N bond cleavage and functioned as sulfamide synthons.
Язык: Английский
Процитировано
2Tetrahedron, Год журнала: 2024, Номер 162, С. 134119 - 134119
Опубликована: Июнь 20, 2024
Язык: Английский
Процитировано
1Journal of Molecular Structure, Год журнала: 2024, Номер 1323, С. 140621 - 140621
Опубликована: Ноя. 10, 2024
Язык: Английский
Процитировано
1