Fe‐Catalyzed, Solvent‐Controlled, Switchable Routes for the Domino Construction of 2,4‐Disubstituted and 4‐Substituted Quinoline Scaffolds DOI Open Access
Prafull A. Jagtap, Vaishnavi R. Sawant, Bhalchandra M. Bhanage

и другие.

ChemCatChem, Год журнала: 2024, Номер unknown

Опубликована: Июль 27, 2024

Abstract In this report, we unveil a highly efficient novel protocol for the domino synthesis of 2,4‐disubstituted and 4‐substituted quinoline scaffolds. The developed strategy involves earth‐abundant Fe‐catalyzed, solvent‐controlled, switchable routes selective construction frameworks, achieved by using either trifluoroethanol (TFE) or methanol (MeOH) as solvent. By employing TFE solvent in Path A, alkyne itself serves dual synthon through Fe‐catalyzed situ C( sp )–C( ) bond cleavage, enabling two important molecules: quinolines. Later, upon switching reaction medium from to MeOH Path‐B, only quinolines were obtained extensively. oxidation was observed here functioned both an environmentally benign carbon source. Both these strategies utilized prepare broad range mono‐ di‐substituted derivatives. application section practical utility, scale‐up studies, along with photophysical properties synthesized moiety are also demonstrated.

Язык: Английский

One-Pot Formal [3+2] Annulation of 2-Pyridinyl-Substituted p-Quinone Methides and Arynes for the Synthesis of 3-Aryl Pyrido[1, 2-a]indoles DOI

Mengfan Li,

Yan Chen, Hao Tang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(27), С. 5618 - 5628

Опубликована: Янв. 1, 2024

We report a formal [3 + 2] cycloaddition for constructing 3-aryl pyrido[1,2- ]indoles from aryne intermediates and 2-pyridinyl-substituted p -QMs under ambient conditions.

Язык: Английский

Процитировано

1
Fe‐Catalyzed, Solvent‐Controlled, Switchable Routes for the Domino Construction of 2,4‐Disubstituted and 4‐Substituted Quinoline Scaffolds DOI Open Access
Prafull A. Jagtap, Vaishnavi R. Sawant, Bhalchandra M. Bhanage

и другие.

ChemCatChem, Год журнала: 2024, Номер unknown

Опубликована: Июль 27, 2024

Abstract In this report, we unveil a highly efficient novel protocol for the domino synthesis of 2,4‐disubstituted and 4‐substituted quinoline scaffolds. The developed strategy involves earth‐abundant Fe‐catalyzed, solvent‐controlled, switchable routes selective construction frameworks, achieved by using either trifluoroethanol (TFE) or methanol (MeOH) as solvent. By employing TFE solvent in Path A, alkyne itself serves dual synthon through Fe‐catalyzed situ C( sp )–C( ) bond cleavage, enabling two important molecules: quinolines. Later, upon switching reaction medium from to MeOH Path‐B, only quinolines were obtained extensively. oxidation was observed here functioned both an environmentally benign carbon source. Both these strategies utilized prepare broad range mono‐ di‐substituted derivatives. application section practical utility, scale‐up studies, along with photophysical properties synthesized moiety are also demonstrated.

Язык: Английский

Процитировано

1