One-Pot Total Synthesis of Natural Products Nitramarine, Nitraridine, and Analogues via a Cascade Oxidation/Pictet–Spengler Condensation/Annulation Process

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(17), С. 12832 - 12841

Опубликована: Авг. 9, 2024

A cascade oxidation/Pictet–Spengler condensation/annulation process has been developed for the one-pot total synthesis of nitramarine, nitraridine, and their analogues. The procedure proceeded with easily available quinolines tryptophan derivatives. simple metal-free approach, wide substrate scope, functional group tolerance make it applicable diverse bioactive Furthermore, bioactivity evaluation identified two promising leading compounds 5d 5e potent antitumor proliferative activity against breast cancer cells.

Язык: Английский

Copper-Catalyzed, Intramolecular Amination of Unactivated C(sp³)–H Bonds through Radical Relay

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 13077 - 13084

Опубликована: Авг. 29, 2024

Although copper-catalyzed amination of activated C(sp3)–H bonds through radical relay has been developed, unactivated is rare. Herein, intramolecular remote reported. The reaction conducted in a mild and effective manner with moderate to good yields, demonstrating broad tolerance toward various functional groups exhibiting complete regio- chemoselectivities. This innovation supplies novel synthetic pathways for the construction saturated nitrogenated heterocycles.

Язык: Английский