Insight into Stabilization of G‐Quadruplex in c‐MYC Region with Phenanthroimidazoisoindol‐Acrylates and their Binding Behaviour towards Human Serum Albumin DOI Open Access

Rekha Thakur,

Vijay Luxami, Kamaldeep Paul

и другие.

ChemMedChem, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

The interaction of G-quadruplex (non-canonical DNA) with suitable compounds for their stabilization at the promoter region oncogenes has become a potential anticancer approach. We have studied phenanthroimidazoisoindol-acrylates derivatives c-MYC G-quadruplex. A series 20 were evaluated activity against human cancer cell lines, where 3 fa, ha, and ae shown broad-spectrum activities most lines inactive towards normal lines. Various spectroscopic techniques been used to study these compounds. studies reveal strong binding all three significant selectivity over dsDNA, constant order 10

Язык: Английский

Lophine incorporated azo dye as a novel colorimetric sensor for multiple metal ions DOI
Shiv R. Desai,

Vidhi V. Bhopekar,

Rinkal B. Bhoraniya

и другие.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 331, С. 125760 - 125760

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0

Copper‐Catalyzed Oxidative C─N Coupling of Carbazoles with Arylglyoxal Hydrates DOI

Lianji Zhang,

Dalong Pan,

Jinpeng Chu

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(19)

Опубликована: Май 1, 2025

Abstract In this study, a highly efficient Cu‐catalysed oxidative C─N coupling reaction was developed, which successfully achieved the of carbazole with aryl ketone aldehyde hydrates, showing wide range substrate applicability and good functional group tolerance. This method provides novel approach to synthesising diketones elucidates potential mechanism, thus offering significant tool for compounds demonstrating considerable application.

Язык: Английский

Процитировано

0

Insight into Stabilization of G‐Quadruplex in c‐MYC Region with Phenanthroimidazoisoindol‐Acrylates and their Binding Behaviour towards Human Serum Albumin DOI Open Access

Rekha Thakur,

Vijay Luxami, Kamaldeep Paul

и другие.

ChemMedChem, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

The interaction of G-quadruplex (non-canonical DNA) with suitable compounds for their stabilization at the promoter region oncogenes has become a potential anticancer approach. We have studied phenanthroimidazoisoindol-acrylates derivatives c-MYC G-quadruplex. A series 20 were evaluated activity against human cancer cell lines, where 3 fa, ha, and ae shown broad-spectrum activities most lines inactive towards normal lines. Various spectroscopic techniques been used to study these compounds. studies reveal strong binding all three significant selectivity over dsDNA, constant order 10

Язык: Английский

Процитировано

0