Hydride Shuttle Catalysis: From Conventional to Inverse Mode
JACS Au,
Год журнала:
2024,
Номер
4(9), С. 3358 - 3369
Опубликована: Авг. 19, 2024
Hydride
shuttle
catalysis
has
emerged
as
a
powerful
synthetic
platform,
enabling
the
selective
formation
of
C–C
bonds
to
yield
sp3-rich
structures.
By
virtue
compelling
reactivity
sterically
encumbered
Lewis
acids
from
frustrated
pair
regime,
hydride
enables
regioselective
functionalization
alkyl
amines
at
either
α-
or
β-position.
In
contrast
classical
acid
reactivity,
increased
steric
hindrance
prevents
interaction
with
basic
amine
itself,
instead
leading
reversible
abstraction
α-carbon.
The
created
positive
charge
facilitates
occurrence
transformations
before
rebound
similar
capture
event
happen.
this
Perspective,
we
outline
broad
selection
featuring
catalysis,
well
recently
developed
approach
inverse
catalysis.
Both
strategies
give
rise
wide
array
functionalized
and
offer
elegant
approaches
otherwise
elusive
bond
formations.
Язык: Английский
Strategies Employing Transition‐Metal Free Conditions for C−C Bond Formation in Indoles
ChemistrySelect,
Год журнала:
2024,
Номер
9(36)
Опубликована: Сен. 19, 2024
Abstract
Indole
motifs
are
omnipresent
in
nature
and
can
be
found
many
natural
products
as
well
pharmaceuticals.
It
is
for
this
reason
synthetic
transformations
of
indole
have
become
a
topic
interest
the
organic
medicinal
chemist
community
decades.
In
review,
we
emphasized
functionalization
indoles
via
transition‐metal‐free
approaches.
This
review
touches
on
aspects
different
sub‐sections,
which
gives
proposition
tactics
employed
an
overview
road
ahead.
Язык: Английский
π‐Conjugation as a Direct Estimate of Lewis Acidity
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
A
computational
approach
to
directly
estimate
the
relative
acidity
of
a
given
Lewis
acid
is
presented.
This
based
on
strength
π-conjugation
in
trans-crotonaldehyde-Lewis
complexes,
species
used
well-known
Childs'
scale.
It
found
that
π-conjugative
values
by
Energy
Decomposition
Analysis
-
Natural
Orbital
for
Chemical
Valence
method
strongly
correlate
not
only
with
variation
bond
lengths
system,
which
are
greatly
affected
nature
acid,
but
also
downfield
shifts
experienced
different
nuclei
conjugated
system
upon
binding
acid.
These
strong
correlations
indicate
(easy-to-compute)
energies
can
be
as
an
alternative
Язык: Английский