Rhodium(I)‐Catalyzed Asymmetric Cascade Reactions
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Rhodium(I)-catalyzed
asymmetric
cascade
reactions
have
emerged
as
powerful
tools
in
contemporary
organic
synthesis,
enabling
efficient
construction
of
complex
molecular
architectures.
These
transformations
proceed
through
organorhodium
intermediates,
which
undergo
additions
to
reactive
π-bonds,
subsequently
triggering
with
neighboring
functional
groups
effectively
forge
multiple
carbon-carbon
bonds
and
stereogenic
centers
a
single
step
under
mild
conditions.
This
article
reviews
the
pioneering
developments
recent
breakthroughs
from
2002
2024,
highlighting
attractive
advantages
rhodium(I)-catalyzed
their
profound
impacts
on
synthetic
chemistry.
Язык: Английский
Ruthenium and Iodine Anion Cocatalyzed Cascade Dihalogenation and Cyclization of Internal Alkyne-Tethered Cyclohexadienones with 1,2-Dihaloethanes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(13), С. 9686 - 9694
Опубликована: Июнь 22, 2024
We
have
established
an
efficient
ruthenium(II)
and
iodine
anion
cocatalyzed
dihalogenation
cascade
cyclization
of
internal
alkyne-tethered
cyclohexadienones,
which
stereoselectively
afforded
numerous
products
with
a
bioactive
hydrobenzofuran
skeleton
in
high
yields
under
mild
conditions.
In
this
transformation,
the
reaction
pathway
was
determined
by
concentration
electrophilic
reagent,
also
provided
strategy
for
control
selectivity.
Furthermore,
method
features
use
1,2-dihaloroethane
as
halogen
source
via
catalyst.
Язык: Английский