Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

A chiral carbene-catalyzed dynamic kinetic resolution for the facile synthesis of enantioenriched dihydro-1,4-benzoxazine-2-carboxylates is disclosed. The reaction conditions are mild, and a diversity substituents well-tolerated in this transformation. In addition, our methodology also provides an efficient strategy building chromane-2-carboxylate 2,3-dihydro-1,4-benzodioxane-2-carboxylate. optically pure products generated from protocol can be easily derived as key intermediates drugs bioactive molecules.

Язык: Английский