NaHCO3‐promoted Formal [4+3] Annulation of Salicylaldehydes with Isoquinolinium Salts Accessing Isoquinoline‐fused Benzo[f][1,3]oxazepines DOI
Qiang Tang, Yanan Liu,

Mengdi Wu

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Abstract A concise and practical sustainable strategy for modular access to isoquinoline‐fused benzo[ f ][1,3]oxazepine derivatives through a formal [4+3] annulation of commercially available salicyaldehydes with isoquinolinium salts has been developed. The reactions proceeded the formation two new bonds (C=C C−O) seven‐membered heterocyclic ring in one pot. Remarkably, use simple NaHCO 3 as mild base, open atmosphere, nonhazardous reagents, nice functional group tolerance, easily scale up are added characteristics this approach. wide range substrates compatible reaction system, thereby proving facile reliable protocol constructing skeletons.

Язык: Английский

Rh(III)-Catalyzed [4 + 2] Annulation and Dehydrogenative Annulation of N-Chloroimines with Maleimides DOI
Hanxiao Xu, Zhixin Wang,

Xuanzhen Han

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер 90(4), С. 1706 - 1719

Опубликована: Янв. 15, 2025

We herein report a Rh(III)-catalyzed C–H bond coupling of N-chloroimines with maleimides, in which the [4 + 2] annulation and dehydrogenative processes can be selectively achieved by simply adjusting reaction conditions. This protocol is compatible various functional groups, shows exquisite selectivity, presents concise synthetic procedure to respective products moderate good yields. With all these merits, this strategy may applicable construction related azaheterocyclic skeletons.

Язык: Английский

Процитировано

0

Recent Advances for the Transformation of Maleimides via Annulation DOI
Mohammad Aslam, Muhammad Saeed Akhtar, Hee Nam Lim

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review highlights recent advances in maleimide-based annulation and cyclization strategies, offering insights into their synthetic versatility potential applications creating structurally diverse aromatics bioactive heterocycles.

Язык: Английский

Процитировано

1

NaHCO3‐promoted Formal [4+3] Annulation of Salicylaldehydes with Isoquinolinium Salts Accessing Isoquinoline‐fused Benzo[f][1,3]oxazepines DOI
Qiang Tang, Yanan Liu,

Mengdi Wu

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Abstract A concise and practical sustainable strategy for modular access to isoquinoline‐fused benzo[ f ][1,3]oxazepine derivatives through a formal [4+3] annulation of commercially available salicyaldehydes with isoquinolinium salts has been developed. The reactions proceeded the formation two new bonds (C=C C−O) seven‐membered heterocyclic ring in one pot. Remarkably, use simple NaHCO 3 as mild base, open atmosphere, nonhazardous reagents, nice functional group tolerance, easily scale up are added characteristics this approach. wide range substrates compatible reaction system, thereby proving facile reliable protocol constructing skeletons.

Язык: Английский

Процитировано

0