Rh(III)-Catalyzed [4 + 2] Annulation and Dehydrogenative Annulation of N-Chloroimines with Maleimides
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
90(4), С. 1706 - 1719
Опубликована: Янв. 15, 2025
We
herein
report
a
Rh(III)-catalyzed
C–H
bond
coupling
of
N-chloroimines
with
maleimides,
in
which
the
[4
+
2]
annulation
and
dehydrogenative
processes
can
be
selectively
achieved
by
simply
adjusting
reaction
conditions.
This
protocol
is
compatible
various
functional
groups,
shows
exquisite
selectivity,
presents
concise
synthetic
procedure
to
respective
products
moderate
good
yields.
With
all
these
merits,
this
strategy
may
applicable
construction
related
azaheterocyclic
skeletons.
Язык: Английский
Recent Advances for the Transformation of Maleimides via Annulation
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
highlights
recent
advances
in
maleimide-based
annulation
and
cyclization
strategies,
offering
insights
into
their
synthetic
versatility
potential
applications
creating
structurally
diverse
aromatics
bioactive
heterocycles.
Язык: Английский
NaHCO3‐promoted Formal [4+3] Annulation of Salicylaldehydes with Isoquinolinium Salts Accessing Isoquinoline‐fused Benzo[f][1,3]oxazepines
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
A
concise
and
practical
sustainable
strategy
for
modular
access
to
isoquinoline‐fused
benzo[
f
][1,3]oxazepine
derivatives
through
a
formal
[4+3]
annulation
of
commercially
available
salicyaldehydes
with
isoquinolinium
salts
has
been
developed.
The
reactions
proceeded
the
formation
two
new
bonds
(C=C
C−O)
seven‐membered
heterocyclic
ring
in
one
pot.
Remarkably,
use
simple
NaHCO
3
as
mild
base,
open
atmosphere,
nonhazardous
reagents,
nice
functional
group
tolerance,
easily
scale
up
are
added
characteristics
this
approach.
wide
range
substrates
compatible
reaction
system,
thereby
proving
facile
reliable
protocol
constructing
skeletons.
Язык: Английский