Effect of Solvents on Electrogenerated Base-Driven Transfer Hydrogenation Reactions

Molecules, Год журнала: 2025, Номер 30(4), С. 910 - 910

Опубликована: Фев. 15, 2025

Transfer hydrogenation is a crucial technology for synthesizing fine chemicals and pharmaceuticals, offering improved safety convenience over traditional hydrogen methods, although it typically requires external bases. While isopropanol commonly used as source, methanol superior but faces challenges due to its high dehydrogenation energy barrier, limiting use under mild conditions. This study focuses on investigating the differences in electrogenerated base-driven transfer of aromatic ketones solvents, using Mn(CO)₅Br cyclohexanediamine derivatives catalyst. The research demonstrates that enantiomeric excess (ee) values were obtained presence chiral Mn-based catalysts, while only racemic products observed methanol. results indicate strong dependence catalytic pathway choice solvent: isopropanol, catalyst operates via metal-ligand cooperative hydrogenation, resulting ee values, whereas methanol, occurs through metal hydride with no stereoselectivity.

Язык: Английский

Fluorohydrins and where to find them: recent asymmetric syntheses of β-fluoro alcohols and their derivatives

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The present work provides an overview of synthetic approaches to fluorohydrins and their fluorinated group derivatives that have been explored in the past decade, as well selected examples these syntheses applied medicinal chemistry.

Язык: Английский