Advances in Direct Fluoroalkylation of Organic Substrates with Partially Fluorinated Alkyl Motivs DOI
Sebastián Barata‐Vallejo, Sergio M. Bonesi, Al Postigo

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(21), С. 15879 - 15907

Опубликована: Окт. 11, 2024

Partially fluorinated alkyl groups other than methyl are increasingly playing crucial roles in the development of drugs with diverse biological activities, thus creating an innovative chemical space within organofluorine chemistry. For studies structure–activity relationships, late-stage modification such or substituents into substrates that bear activity is essential. This perspective will study catalytic protocols for direct introduction partially monofluoroalkylated (−CHFR, –CH2CH2F), difluoroalkylated (−CF2Me, –CH2CF2H), trifluoroalkylated (−CHR(CF3), –CH2CF3, –CH2CH2CF3, –CH(Me)CF3, –C(Me)2CF3), and pentafluoropropylated (−CH2C2F5) onto (hetero)aromatic compounds, double bonds, isonitriles, halides, N, O, S atoms.

Язык: Английский

Advances in Direct Fluoroalkylation of Organic Substrates with Partially Fluorinated Alkyl Motivs DOI
Sebastián Barata‐Vallejo, Sergio M. Bonesi, Al Postigo

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(21), С. 15879 - 15907

Опубликована: Окт. 11, 2024

Partially fluorinated alkyl groups other than methyl are increasingly playing crucial roles in the development of drugs with diverse biological activities, thus creating an innovative chemical space within organofluorine chemistry. For studies structure–activity relationships, late-stage modification such or substituents into substrates that bear activity is essential. This perspective will study catalytic protocols for direct introduction partially monofluoroalkylated (−CHFR, –CH2CH2F), difluoroalkylated (−CF2Me, –CH2CF2H), trifluoroalkylated (−CHR(CF3), –CH2CF3, –CH2CH2CF3, –CH(Me)CF3, –C(Me)2CF3), and pentafluoropropylated (−CH2C2F5) onto (hetero)aromatic compounds, double bonds, isonitriles, halides, N, O, S atoms.

Язык: Английский

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