Ni‐Catalyzed Cross‐Electrophile Couplings of N‐Alkoxyphthalimides and Aryl Halides
European Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 13, 2025
N
‐alkoxyphthalimides
represent
a
versatile
class
of
redox‐active
alcohol
derivatives
for
carbon–carbon
bond
formation
following
activation
by
single‐electron
reduction.
Herein,
key
precedents
using
the
new
bonds
under
photochemical
reaction
conditions
are
first
presented.
The
merger
these
and
other
strategies
with
Ni
catalysis
in
various
cross‐electrophile
couplings
aryl
halides
is
then
highlighted.
A
particular
focus
made
on
mechanisms
proposed
Ni‐catalyzed
reductive
cross‐couplings.
Concluding
thoughts
future
design
as
C(sp
3
)O
transition
metal‐catalyzed
cross‐couplings
also
Язык: Английский
Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide
Molecules,
Год журнала:
2024,
Номер
29(24), С. 6016 - 6016
Опубликована: Дек. 20, 2024
Nitriles
are
valuable
compounds
because
they
have
widespread
applications
in
organic
chemistry.
This
report
details
the
nickel-catalyzed
reductive
cyanation
of
aryl
halides
and
epoxides
with
cyanogen
bromide
for
synthesis
nitriles.
robust
protocol
underscores
practicality
using
a
commercially
available
cost-effective
reagent.
A
variety
featuring
diverse
functional
groups,
such
as
-TMS,
-Bpin,
-OH,
-NH2,
-CN,
-CHO,
were
successfully
converted
into
nitriles
moderate-to-good
yields.
Moreover,
syntheses
at
gram-scale
application
late-stage
natural
products
drugs
reinforces
its
potentiality.
Язык: Английский