Synthesis of Isoquinoline N-Oxides via Hypervalent Iodine-Mediated Oxidative Cyclization of Ketoximes with Alkenes DOI Creative Commons
Aurapat Ngamnithiporn, Padon Chuentragool,

Supakarn Punnita

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Reported herein is the development of an intramolecular oxidative cyclization ketoximes with alkenes for preparation isoquinoline N-oxides. The reaction, which utilizes phenyliodine bis(trifluoroacetate) (PIFA) as oxidant and 2,2,2-trifluoroethanol (TFE) a solvent, proceeds to afford various N-heterocyclic products, including aryl/heteroaryl-fused pyridine N-oxides, isoindole 2-benzazepine derivatives. Preliminary experimental computational mechanistic studies suggest that ionic pathway primary mechanism. synthetic utility developed method was highlighted via several product transformations.

Язык: Английский

Synthesis of Isoquinoline N-Oxides via Hypervalent Iodine-Mediated Oxidative Cyclization of Ketoximes with Alkenes DOI Creative Commons
Aurapat Ngamnithiporn, Padon Chuentragool,

Supakarn Punnita

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Reported herein is the development of an intramolecular oxidative cyclization ketoximes with alkenes for preparation isoquinoline N-oxides. The reaction, which utilizes phenyliodine bis(trifluoroacetate) (PIFA) as oxidant and 2,2,2-trifluoroethanol (TFE) a solvent, proceeds to afford various N-heterocyclic products, including aryl/heteroaryl-fused pyridine N-oxides, isoindole 2-benzazepine derivatives. Preliminary experimental computational mechanistic studies suggest that ionic pathway primary mechanism. synthetic utility developed method was highlighted via several product transformations.

Язык: Английский

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