Rh(III)‐Catalyzed C‐H Cyclization of 2‐Arylbenzimidazoles with CF3‐Imidoyl Sulfoxonium Ylides and Further Sc(III)‐Catalyzed Deaminative Hydroxylation
Juting Liao,
Ruirui Zhai,
Xiaoyang Gao
и другие.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
Abstract
An
efficient
Rh(III)‐catalyzed
C−H
bond
activation/cyclization
of
2‐arylbenzimidazoles
with
CF
3
‐imidoyl
sulfoxonium
ylides
has
been
achieved,
yielding
diverse
−
and
amino‐disubstituted
5,6‐dihydrobenzoimidazo[2,1‐
a
]isoquinolines,
which
could
undergo
deaminative
hydroxylation
to
access
hydroxy‐disubstituted
]isoquinolines
catalyzed
by
Sc(OTf)
.
This
developed
strategy
features
easily
available
starting
materials,
broad
substrate
scope,
good
scalability
high
efficiency.
Moreover,
the
antitumor
activities
selected
products
against
some
human
cancer
cell
lines
were
also
investigated,
results
indicated
that
several
show
antiproliferative
activities.
Язык: Английский
Synthesis of CF3-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF3-Imidoyl Sulfoxonium Ylides
Molecules,
Год журнала:
2025,
Номер
30(1), С. 183 - 183
Опубликована: Янв. 5, 2025
An
efficient
Rh(III)-catalyzed
C-H
activation
of
azobenzenes
and
subsequent
[4+1]
cascade
annulation
with
CF3-imidoyl
sulfoxonium
ylides
was
developed,
yielding
diverse
CF3-indazoles.
This
protocol
featured
easily
available
starting
materials,
excellent
functional
group
tolerance
high
efficiency.
Moreover,
the
antitumor
activities
selected
CF3-indazoles
against
human
cancer
cell
lines
were
also
studied,
results
indicated
that
several
compounds
displayed
considerable
antiproliferative
activities.
Язык: Английский
Condition-Controlled Rh(III)-Catalyzed Chemodivergent Cyclization of 2-Arylpyridines with CF3-Imidoyl Sulfoxonium Ylides via Triple C–H Activation
Xiaoyang Gao,
Ruirui Zhai,
Juting Liao
и другие.
Organic Letters,
Год журнала:
2025,
Номер
27(2), С. 657 - 662
Опубликована: Янв. 7, 2025
A
condition-controlled
Rh(III)-catalyzed
selective
synthesis
of
CF3-substituted
indoles
and
pyrido[2,1-a]isoindoles
from
2-arylpyridines
CF3-imidoyl
sulfoxonium
ylides
has
been
developed.
The
Cp*Rh(MeCN)3(SbF6)2/HFIP
system
afforded
via
triple
C–H
activation,
while
the
[Cp*RhCl2]2/MeCN
condition
selectively
furnished
through
[4
+
1]
annulation.
notable
advantages
this
developed
method
included
readily
available
starting
materials,
broad
substrate
scope,
excellent
chemoselectivity.
Importantly,
several
selected
products
showed
promising
antitumor
activities.
Язык: Английский
Organic Base-Catalyzed Cascade Reaction of CF3–Iminopropargylic Alcohols with Carboxylic Acids: an Approach to β-CF3 β-Aminoenones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
A
novel
approach
to
the
synthesis
of
β-CF3
β-aminoenones
by
organic
amine
base-catalyzed
reaction
CF3-iminopropargylic
alcohols
with
carboxylic
acids
is
reported.
The
advantages
protocol
are
ease
operation,
available
starting
materials,
and
simple
tertiary
catalysts.
Язык: Английский
Synthesis of Spiro 3,3′-Cyclopropyl Oxindoles via Cyclopropanation of 3-Alkenyl-oxindoles with CF3-Imidoyl Sulfoxonium Ylides
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
A
catalyst
and
additive-free
[2+1]
annulation
of
3-alkenyl-oxindoles
with
CF3-imidoyl
sulfoxonium
ylides
(TFISYs)
for
the
construction
spiro
3,3'-cyclopropyl
oxindoles
has
been
achieved.
cascade
intermolecular
Micheal-addition
reaction
intramolecular
nucleophilic
substitution
sequence
might
be
involved
in
transformation,
which
afforded
a
wide
range
multisubstituted
oxindole
products
high
efficiency
diastereoselectivity.
Язык: Английский
Water-Involved 1,3-Aminoxylation of Fluoroalkenes: Chemo-, Regio-, and Stereoselective Synthesis of β-Fluoroacyl Vinylamines
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Perfluoroalkyl
alkenyl
iodides
(PFAIs)
are
emerging
as
highly
reactive,
storage-stable,
and
multifunctional
fluoroalkyl-bearing
reagents,
facilitating
the
manufacture
of
value-added
organofluorides
through
multi-halo-functionalization.
Herein,
we
developed
a
water-involved
1,3-aminoxylation
PFAIs
with
sulfonamides
for
chemo-,
regio-,
Z-stereoselective
synthesis
valuable
β-fluoroacyl
vinylamines.
This
reaction
proceeded
via
sequential
deiodoamination
defluoroxylation
process
under
transition-metal-free
conditions,
featuring
broad
substrate
scope
good
functional
group
tolerance.
Compared
to
reported
methods,
some
drawbacks,
such
multistep
manipulation,
harsh
need
expensive
catalysts,
use
toxic/sensitive
could
be
eliminated.
Furthermore,
synthetic
potential
this
method
was
demonstrated
scale-up
synthesis,
postfunctionalization
complex
molecules,
ready
transformation
products.
Язык: Английский