Brønsted Acid Mediated Mono- and Di-substitution of Quinoxalines with Indoles: A Pathway to Indolocarbazole-Quinoxaline Scaffolds

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A versatile and efficient protocol for the mono- di-substitution of quinoxalines with indoles has been developed, offering a direct pathway to indolocarbazole-quinoxaline scaffolds. By optimizing reaction conditions, selective coupling at C-2 C-3 positions diverse indole derivatives was achieved under transition metal-free conditions. Substrate scope evaluation revealed broad functional group tolerance synthetic utility demonstrated by gram-scale synthesis subsequent cyclization into novel indolocarbazole-quinoxalines. Mechanistic studies suggest an ionic pathway, highlighting potential this method constructing biologically relevant heterocyclic architectures.

Язык: Английский

Electrochemical C H Thiocyanation/Halogenation of 4-Arylthioazol-2-ones

Molecular Catalysis, Год журнала: 2025, Номер 583, С. 115210 - 115210

Опубликована: Май 22, 2025

Язык: Английский