Copper-Catalyzed and 1,3-Sulfonyl Migration Enabled Installation of Azaindoles in the Periphery of Aryl Rings: Synthesis of Sulfonylated Pyrrolo[2,3-b]quinolines and Investigation of Antimalarial Potency DOI
Shivani Choudhary,

Gayyur,

Siddhant

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Herein, an atom efficient and one-pot protocol, offering a series of sulfonylated pyrrolo[2,3-b]quinolines via C-N, C-C, C-S bond formation, has been developed with inexpensive copper catalyst. Notably, the reaction proceeds double-annulation followed by 1,3-sulfonyl migration sequence. Moreover, method is applicable to broad range 2-carbonylanilines. Furthermore, synthetic applications scale-up highlight utility potential this protocol. In addition, antimalarial property showed parasite inhibition without cytotoxic effects in mammalian cells.

Язык: Английский

Copper-Catalyzed and 1,3-Sulfonyl Migration Enabled Installation of Azaindoles in the Periphery of Aryl Rings: Synthesis of Sulfonylated Pyrrolo[2,3-b]quinolines and Investigation of Antimalarial Potency DOI
Shivani Choudhary,

Gayyur,

Siddhant

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Herein, an atom efficient and one-pot protocol, offering a series of sulfonylated pyrrolo[2,3-b]quinolines via C-N, C-C, C-S bond formation, has been developed with inexpensive copper catalyst. Notably, the reaction proceeds double-annulation followed by 1,3-sulfonyl migration sequence. Moreover, method is applicable to broad range 2-carbonylanilines. Furthermore, synthetic applications scale-up highlight utility potential this protocol. In addition, antimalarial property showed parasite inhibition without cytotoxic effects in mammalian cells.

Язык: Английский

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