Microwave-Promoted Synthesis of 1-Tetralones via Iminyl Radical-Mediated 1,5-Hydrogen Atom Transfer DOI

Spencer A. Jones,

Jesús Botello, Jatinder Singh

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Microwave irradiation of O-phenyloximes produces 1-tetralones via N-O homolysis, 1,5-hydrogen atom transfer (HAT), and cyclization a radical intermediate onto an aromatic ring. The HAT step is facilitated by coordination Lewis acid InCl3·H2O to iminyl radical. reaction rapid exhibits broad substrate scope. A larger scale transformation can be performed using conventional heating instead microwave irradiation.

Язык: Английский

Microwave-Promoted Synthesis of 1-Tetralones via Iminyl Radical-Mediated 1,5-Hydrogen Atom Transfer DOI

Spencer A. Jones,

Jesús Botello, Jatinder Singh

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Microwave irradiation of O-phenyloximes produces 1-tetralones via N-O homolysis, 1,5-hydrogen atom transfer (HAT), and cyclization a radical intermediate onto an aromatic ring. The HAT step is facilitated by coordination Lewis acid InCl3·H2O to iminyl radical. reaction rapid exhibits broad substrate scope. A larger scale transformation can be performed using conventional heating instead microwave irradiation.

Язык: Английский

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