Visible Light-Promoted Ir(III)-Catalyzed Stereoselective Synthesis of Azauracil-C-Nucleosides from 1-Bromosugar DOI

Ramanand Das,

Norein Sakander,

Sanchari Kundu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

A visible light-promoted, mild, and efficient Ir(III)-catalyzed synthesis of C-nucleosides is reported, utilizing 1-bromosugar as the glycosyl radical precursor 6-azauracil nucleobase. The method exhibits high α-selectivity excellent functional group tolerance. Spectroscopic evidence shows that coupling reaction happens via initial reductive quenching Ir(III) catalyst under light. Density theory calculation reveals reason for complete α-selectivity. Finally, biologically active 6-aza pseudouridine analogues were synthesized, making process a valuable platform C-nucleosides.

Язык: Английский

Silver-catalyzed direct decarboxylative C H functionalization of azauracils with aliphatic carboxylic acids DOI
Jie Zeng, Hong Zhou, Shenghao Wang

и другие.

Tetrahedron Letters, Год журнала: 2025, Номер unknown, С. 155619 - 155619

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Visible Light-Promoted Ir(III)-Catalyzed Stereoselective Synthesis of Azauracil-C-Nucleosides from 1-Bromosugar DOI

Ramanand Das,

Norein Sakander,

Sanchari Kundu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

A visible light-promoted, mild, and efficient Ir(III)-catalyzed synthesis of C-nucleosides is reported, utilizing 1-bromosugar as the glycosyl radical precursor 6-azauracil nucleobase. The method exhibits high α-selectivity excellent functional group tolerance. Spectroscopic evidence shows that coupling reaction happens via initial reductive quenching Ir(III) catalyst under light. Density theory calculation reveals reason for complete α-selectivity. Finally, biologically active 6-aza pseudouridine analogues were synthesized, making process a valuable platform C-nucleosides.

Язык: Английский

Процитировано

0