An Oxygen Walk Approach for C3 Selective Hydroxylation of Pyridines

Synlett, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Abstract Selective C3 functionalization of unbiased pyridines represents a significant challenge in organic synthesis. While seminal work this area has enabled access to various C3-substituted via dearomatized intermediates, the direct introduction hydroxy group at position is still challenging. In context, we have developed valence isomerization reaction triggered by photoexcitation pyridine N-oxides deliver synthetically challenging C3-hydroxy products. 1 Introduction 2 Recent Advances Radical-Based Pyridine Functionalization N-Oxides 3 C3-Selective Hydroxylation Pyridines through Oxygen Walking 4 Conclusion

Язык: Английский

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Photocatalytic C−H Functionalization Utilizing Acridine−Lewis Acid Complexes and Pyridine N-oxide Based HAT Catalysts

Tetrahedron, Год журнала: 2025, Номер 181, С. 134683 - 134683

Опубликована: Апрель 26, 2025

Язык: Английский

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Visible-light Mediated Oxidative Diels-Alder Reaction of Hydroxylamines and 1,3-Dienes

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134752 - 134752

Опубликована: Май 1, 2025

Язык: Английский

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Inhibition of Kornblum Reaction with Lithium Salts in S_N2 Reactions of Sulfonates and a Nucleophile Containing a Pyridine N-Oxide Moiety: Convergent and Selective Synthesis of an MRGPRX2 Antagonist

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

A critical step in the development of a convergent synthesis an MRGPRX2 antagonist (

Язык: Английский

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Fluorescent N-Oxides: Applications in Bioimaging and Sensing

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(37), С. 7582 - 7595

Опубликована: Янв. 1, 2024

-Oxides, due to their zwitterionic nature and ability form hydrogen bonds through the oxide ion, are highly water-soluble widely used in biological pharmacological studies. The

Язык: Английский

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