Assembly of Diverse Allenes via Activator-Free Palladium-Catalyzed Regioselective γ-Arylation of Propargylamines with Boronic Acids

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Controlling the reaction selectivity to achieve a precision synthesis is constant concern for chemists. Here, we report palladium-catalyzed deaminative coupling of propargylamines with arylboronic acids generate allene skeletons. Importantly, this approach allows regioselective γ-arylation unactivated propargyl tertiary amines access various allenes in absence amino-activating reagents. We present wide range and boronic demonstrate synthetic application target products construct valuable compounds.

Язык: Английский

Highly efficient synthesis of di-substituted allenes via copper-catalyzed SN2’- substitution reaction of organotitanium reagents with propargyl bromides

Tetrahedron, Год журнала: 2024, Номер unknown, С. 134345 - 134345

Опубликована: Окт. 1, 2024

Язык: Английский