Direct Cross-Couplings of Aryl Nonaflates with Aryl Bromides under Nickel Catalysis
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
The
direct
cross-couplings
of
aryl
nonaflates
with
bromides
could
be
successfully
accomplished
by
utilizing
nickel
as
the
catalyst,
magnesium
metal
mediator,
and
lithium
chloride
additive.
reactions
proceeded
efficiently
in
THF
at
room
temperature
to
produce
desired
biaryls
moderate
good
yields,
showing
both
a
reasonable
substrate
scope
functional
group
tolerance.
Additionally,
an
equally
performance
realized
when
reaction
was
subjected
scale-up
synthesis.
Preliminary
study
suggested
that
presumably
proceeds
through
situ
formation
arylmagnesium
reagent
key
intermediate.
Язык: Английский
Synthesis of Polyfluorinated Biaryls via Palladium-Catalyzed Decarboxylative Cross-Coupling of Zinc Polyfluorobenzoates with Aryl Fluorosulfates
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
A
palladium-catalyzed
decarboxylative
cross-coupling
of
zinc
polyfluorobenzoates
with
aryl
fluorosulfates,
which
proceeded
efficiently
via
C-O
bond
cleavage
to
afford
the
corresponding
polyfluorinated
biaryls
in
moderate-to-good
yields,
was
developed.
The
reactions
exhibited
both
good
substrate
scope
and
broad
functional
group
compatibility,
it
could
be
scaled-up
easily.
synthetic
simplicity
practicability
reaction
further
demonstrated
by
one-pot
manipulation
directly
mixing
polyfluorobenzoic
acid
Zn(OH)2
coexistence
fluorosulfate
a
palladium
catalyst
one
flask.
Further
studies
showed
that
is
more
robust
than
other
halides
pseudohalides
as
arylating
reagent,
polyfluorobenzoate
effective
polyfluoroarylating
agent
their
magnesium
potassium
counterparts.
Язык: Английский
Magnesium-Mediated Three-Component Reductive Cross-Couplings of Aryl Aldehydes, Aryl Bromides, and Aryl 2-Pyridyl Esters: An Efficient Synthesis of Diarylmethanol Esters
Tetrahedron,
Год журнала:
2025,
Номер
unknown, С. 134558 - 134558
Опубликована: Фев. 1, 2025
Язык: Английский
Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Unreactivated Alkyl Chlorides: A Universal Synthesis of Aryl-Alkyl and Dialkyl Ketones via Dynamic Halide Exchange
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
Ni-catalyzed
reductive
coupling
of
2-pyridyl
esters
with
unactivated
primary
and
secondary
alkyl
chlorides
provides
direct
access
to
aryl–alkyl
dialkyl
ketones.
High
selectivity
can
be
achieved
by
rate-matching
via
dynamic
halide
exchange.
Язык: Английский
Iron‐Mediated Desulfonylative Cross‐Electrophile Couplings of Heteroaryl Sulfones with Thiosulfonates for Efficient Synthesis of Heteroaryl Sulfides
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Comprehensive
Summary
A
desulfonylative
thiolation
between
heteroaryl
sulfones
and
thiosulfonates
for
the
efficient
synthesis
of
sulfides
was
developed.
The
cross‐electrophile
couplings
proceeded
effectively
via
old
C–SO
2
bond
cleavage
new
C–S
formation
in
presence
cheapest
widely
available
iron
powder
as
mediator
under
transition
metal
catalyst‐free
conditions,
leading
to
a
wide
array
derived
from
benzo[
d
]thiazole,
]oxazole,
thiazole,
1,3,4‐thiadiazole,
1
H
‐tetrazole
modest
excellent
yields.
In
addition,
reaction
exhibited
good
functional
group
compatibility,
protocol
could
also
be
applicable
use
selenosulfonate
substrate
subjected
scale‐up
with
equal
ease.
Notably,
unreacted
readily
recovered
after
by
resorting
attracting
property
magnetic
stir
bar
iron.
Язык: Английский