Visible-Light-Induced Decarboxylative Annulation of α,β-Unsaturated Acids with Amines and α-Keto Acids for 2,4-Diarylquinoline Synthesis
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
An
efficient
and
sustainable
approach
for
the
synthesis
of
2,4-diarylquinolines
has
been
developed
via
a
visible-light-promoted
metal-free
three-component
decarboxylative
annulation
pathway.
This
one-pot
protocol
combines
readily
available
feed-stock
α,β-unsaturated
acids,
aromatic
amines,
α-keto
acids
in
cascade
manner
to
access
substituted
quinolines
under
eco-benign
conditions.
Moreover,
mechanistic
insights
suggest
initial
C-C
cross
coupling
followed
by
6π
electrocyclic
afford
desired
products.
The
broad
substrates
scope
excellent
functional
group
tolerance
make
this
more
attractive
synthetically
applicable
toward
construction
complex
N-heterocycles.
Язык: Английский
Recent Advances in the Catalytic Synthesis of α‐Ketoamides
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
α
‐Ketoamides
are
privileged
chemical
entities
featuring
a
carbonyl
group
bonded
to
an
amide.
Bearing
two
pronucleophilic
and
proelectrophilic
sites,
this
structural
scaffold
exhibits
distinct
properties
unparalleled
biological
activity.
Owing
its
wide
application
in
medicinal,
agricultural,
synthetic
chemistry,
methods
for
assembling
moiety
ever‐growing
demand.
With
the
increasing
focus
on
green
synthesis,
traditional
routes
‐ketoamides
have
faded
recent
years
giving
rise
development
of
photocatalytic,
electrosynthetic,
microwave‐assisted
catalytic
protocols.
We
hereby
provide
comprehensive
critical
summary
all
advancements
witnessed
field
from
2016
present.
Язык: Английский