New Opportunities to Access Fluorinated Molecules Using Organophotoredox Catalysis via C(sp3)–F Bond Cleavage
JACS Au,
Год журнала:
2025,
Номер
5(2), С. 466 - 485
Опубликована: Фев. 7, 2025
Fluorinated
molecules
are
of
paramount
importance
because
their
unique
properties.
As
a
result,
the
search
for
innovative
approaches
to
synthesis
this
class
compounds
has
been
relentless
over
years.
Among
these,
combination
photocatalysis
and
organofluorine
chemistry
turned
out
be
an
effective
partnership
access
unattainable
fluorinated
molecules.
This
Perspective
provides
overview
recent
advances
in
synthesizing
via
organophotoredox-catalyzed
defluorination
process
from
trifluoromethylated
compounds.
It
encompasses
preparation
difluoromethylated
(hetero)arenes,
amides,
esters
as
well
gem-difluoroalkene
derivatives
using
C(sp3)–F
bond
activation
or
β-fragmentation.
will
highlight
remaining
challenges
discuss
future
research
opportunities.
Язык: Английский
Visible-Light-Induced Synergistic W/Cr Catalyzed gem-Difluoroallylation of Unactivated Alkanes
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Currently,
the
scope
of
Nozaki-Hiyama-Kishi
(NHK)
reaction
is
limited
to
aldehydes
and
ketones
construct
alcohol
derivatives.
Herein,
we
have
described
a
visible-light-induced
synergistic
W/Cr(III)-catalyzed
NHK-type
gem-difluoroallylation
unactivated
cyclic
linear
alkanes.
The
merits
feedstock
materials,
mild
conditions,
wide
functionality
tolerance.
Mechanistic
studies
imply
favorable
reduction
CrCl3
CrCl2
by
reduced
decatungstate
W10O325-,
thus
closing
catalytic
cycle.
Язык: Английский