The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Herein, we describe the photomediated radical cascade addition-cyclization of N-butenoyl tetrahydroquinolines to access various functionalized julolidine-5-one. The scope methodology was illustrated with several sulfonyl chlorides and tetrahydroquinolines. Other precursors, such as trifluoromethyl, bromoacetonitrile, bromoacetates, etc., also worked efficiently, demonstrating broad utility method. Finally, large-scale synthesis sulfonyl-substituted julolidine-5-one downstream conversions synthesized julolidine derivatives were carried out illustrate synthetic methodology.

Язык: Английский