I2-Induced Metal-Free C(sp2)–H Functionalization of Indoles via One-Pot and Two-Step Reaction with 1-(2-Hydroxyphenyl)-propargyl Alcohols: Access to 3-(Benzofuran-3-yl)-1H-indoles DOI

Yang Zhu,

Guisheng Deng

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

The I2-catalyzed reaction of 1-(2-hydroxyphenyl)-propargyl alcohols with indoles and subsequent treatment K2CO3 provided (benzofuran-3-yl)-1H-indoles in good to excellent yields high regioselectivity. This one-pot two-step strategy proved be suitable for a wide range substrates except aliphatic alkynyl as well the bearing N-protected groups such Ts group possessing strong electron-withdrawing feature. procedure involved cross-coupling construction benzofuran framework via 5-exo-dig cyclization.

Язык: Английский

I2-Induced Metal-Free C(sp2)–H Functionalization of Indoles via One-Pot and Two-Step Reaction with 1-(2-Hydroxyphenyl)-propargyl Alcohols: Access to 3-(Benzofuran-3-yl)-1H-indoles DOI

Yang Zhu,

Guisheng Deng

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

The I2-catalyzed reaction of 1-(2-hydroxyphenyl)-propargyl alcohols with indoles and subsequent treatment K2CO3 provided (benzofuran-3-yl)-1H-indoles in good to excellent yields high regioselectivity. This one-pot two-step strategy proved be suitable for a wide range substrates except aliphatic alkynyl as well the bearing N-protected groups such Ts group possessing strong electron-withdrawing feature. procedure involved cross-coupling construction benzofuran framework via 5-exo-dig cyclization.

Язык: Английский

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