Polycyclic aromatic compounds, Год журнала: 2022, Номер 43(1), С. 288 - 301
Опубликована: Янв. 4, 2022
Язык: Английский
European Journal of Medicinal Chemistry, Год журнала: 2019, Номер 180, С. 486 - 508
Опубликована: Июль 15, 2019
Язык: Английский
Процитировано
361
Medicinal Research Reviews, Год журнала: 2021, Номер 42(1), С. 513 - 575
Опубликована: Авг. 28, 2021
Abstract This review article proposes a comprehensive report of the design strategies engaged in development various sulfur‐bearing cytotoxic agents. The outcomes studies depict that sulfur heterocyclic framework is fundamental structure diverse synthetic analogs representing myriad scope therapeutic activities. A number five‐, six‐ and seven‐membered sulfur‐containing scaffolds, such as thiazoles, thiadiazoles, thiazolidinediones, thiophenes, thiopyrans, benzothiazoles, benzothiophenes, thienopyrimidines, simple modified phenothiazines, thiazepines have been discussed. subsequent derivatives unveiled their effects through multiple mechanisms (viz. inhibition tyrosine kinases, topoisomerase I II, tubulin, COX, DNA synthesis, PI3K/Akt Raf/MEK/ERK signaling pathways), several others. Thus, our concise illustration explains strategy anticancer potential these five‐ six‐membered molecules along with brief outline on heterocycles. thorough assessment antiproliferative activities reference drug allows proficient structure–activity relationships (SARs) diversely synthesized series.
Язык: Английский
Процитировано
79
Chemistry & Biodiversity, Год журнала: 2023, Номер 21(2)
Опубликована: Дек. 21, 2023
The prevalence of diabetes mellitus is on the rise, which demands identification novel antidiabetic drugs. There a need for safer and more effective alternatives because therapy methods now available to manage have limits. Due their diverse pharmacological characteristics, heterocyclic molecules with nitrogen Sulfur atoms become intriguing candidates in medicinal chemistry. These substances wide variety structures that can be customized target different pathways associated affect important biological targets involved glucose homeostasis. This review provides thorough summary most recent studies analogues as prospective agents. examines structural forms, action, assesses results preclinical clinical investigations effectiveness safety. Additionally, further optimization development innovative medications are highlighted, well difficulties prospects future utilizing therapeutic potential these analogues. study seeks stimulate additional investigation cooperation between researchers chemists, promoting improvements creation efficient secure medicines fulfill needs management diabetes.
Язык: Английский
Процитировано
26
Anti-Cancer Agents in Medicinal Chemistry, Год журнала: 2022, Номер 22(19), С. 3196 - 3207
Опубликована: Апрель 5, 2022
Abstract: Cancer, a crucial global health problem, is characterized by abnormal cell division and uncontrolled growth. According to WHO, cancer the second leading cause of deaths accounted for approximately 9.6 million or one in six 2018. The National Cancer Registry Programme Report 2020, released ICMRIndia, estimated that there would be 13,90,000 cases India 2020 this number likely rise 15,70,000 2025. In spite several anti-cancer drugs, cannot cured completely, especially at late stages. current era, almost every person suffering from some kind disease. Thus, it necessity time develop novel, potent bioactive molecules. Many researchers are working on development new lead molecules finding biological target betterment human beings. However, heterocycles constantly being used discovery clinically approved drugs contain heterocyclic core as these show exhilarating pharmaceutical properties, including agents such methotrexate, vinblastine, vincristine, daunorubicin, 5-fluorouracil, doxorubicin, etc. compounds provide fascinating research area design drug(s). Herein, we focused natural well synthetic compounds. Furthermore, efforts have been made toward mechanism action selected
Язык: Английский
Процитировано
33
Chemical Communications, Год журнала: 2020, Номер 56(26), С. 3781 - 3784
Опубликована: Янв. 1, 2020
A facile amino group ortho-directed visible-light-driven copper-catalysed aerobic oxidative C(sp)-S coupling reaction of a dimer 2-aminothiophenol with terminal alkynes was achieved. This photochemical shows an excellent conversion and chemoselectivity towards the formation has been employed for wide range thiol dimers, alkynes. Furthermore, synthetic utility synthesized alkynyl sulfides demonstrated as direct method construction 2-phenylbenzothiazoles from corresponding via "thia-Wolff rearrangement" using AgNO3 visible light 9-mesityl-10-methylacridinium ions (Acr+-Mes) photoredox catalyst system.
Язык: Английский
Процитировано
34
The Journal of Organic Chemistry, Год журнала: 2021, Номер 86(9), С. 6289 - 6304
Опубликована: Апрель 19, 2021
A one-pot two-step protocol for the synthesis of 2-acetyl-1H-pyrroles from N-propargylic β-enaminones was described. When treated with zinc chloride in refluxing chloroform, produced situ 2-methylene-2,3-dihydro-1,4-oxazepines, which, upon further methanol chloride, afforded 2-acetyl-1H-pyrroles. The process found to be general a wide variety and yielded diverse range good high yields large substrate scope functional group tolerance. This operationally easy method may provide rapid access functionalized pharmacological interest.
Язык: Английский
Процитировано
21
Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
A simple methodology for the synthesis of bicyclic 6,7-dihydrofuro[3,4- c ]pyridines is reported. The skeletal diversity synthesized heterobicyclic frame may present new nitrogen- and oxygen-based hybrid systems medicinal chemistry.
Язык: Английский
Процитировано
0
Journal of Heterocyclic Chemistry, Год журнала: 2020, Номер 57(9), С. 3255 - 3270
Опубликована: Июль 20, 2020
Abstract Benzothiazepine, a prominent “drug prejudice core”, is heterocyclic moiety of immense importance due to its presence in wide range bioactive compounds. They act as primary “biolinker” diverse synthetic routes obtain molecules and serve important templates medicinal chemistry. are known possess plethora pharmacological activities, which include Ca 2+ channel blockers, CNS acting agents, anti‐HIV, ACE inhibitors, antimicrobial, antifungal, anticancer. Their promising behaviour drug led the scientific community develop novel, mild, green, highly efficient for their synthesis. The conventional synthesis generally involved condensation chalcones with 2‐aminothiophenol acid/base high‐temperature heating, mostly resulting poor yields or mixtures. However, recent trends replacing these conditions mild green through organocatalysis other methodologies. In this review, an attempt has been made by authors summarize (a) Recent developments strategies 1,5‐benzoathiazepines derivatives (b) Conventional methods 1,5‐benzothiazepines including progress chemistry (c) Applications various metals organocatalysts achieve enantioselective title
Язык: Английский
Процитировано
21
Organic Chemistry Frontiers, Год журнала: 2018, Номер 5(21), С. 3103 - 3107
Опубликована: Янв. 1, 2018
The
synthesis
of
2,3,4-trisubstituted
pyrroles
Язык: Английский
Процитировано
22
The Journal of Organic Chemistry, Год журнала: 2020, Номер 85(7), С. 4937 - 4950
Опубликована: Март 10, 2020
A facile and efficient method for the synthesis of 3-[(4-nitrophenyl)thio]-substituted 4-methylene-1-pyrrolines is described. When treated with 4-nitrobenzenesulfenyl chloride in refluxing acetonitrile, N-propargylic β-enaminones produced α-sulfenylated β-enaminones, which, presence sodium hydride or cesium carbonate, underwent nucleophilic cyclization to afford 4-methylene-3-[(4-nitrophenyl)thio]-1-pyrrolines good high yields. It was shown first time that on β-enaminone systems, α-sulfenylation dominates over formation thiirenium ion. This one-pot two-step process found be general a variety demonstrated tolerance diversity aromatic heteroaromatic groups electron-withdrawing electron-donating substituents. also applicable internal alkyne-tethered β-enaminones. The enrichment 1-pyrroline core an aryl sulfide moiety might exhibit potential molecules pharmacological interest.
Язык: Английский
Процитировано
20