The 100 facets of the Passerini reaction

Chemical Science, Год журнала: 2021, Номер 12(47), С. 15445 - 15472

Опубликована: Янв. 1, 2021

This perspective aims at celebrating the 100th anniversary of discovery Passerini three component reaction.

Язык: Английский

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“Isocyanates and isocyanides - life-threatening toxins or essential compounds?”

The Science of The Total Environment, Год журнала: 2024, Номер 934, С. 173250 - 173250

Опубликована: Май 16, 2024

Язык: Английский

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Rapid and Scalable Synthesis of Oxazoles Directly from Carboxylic Acids

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

A highly efficient and expedient method for the synthesis of 4,5-disubstituted oxazoles has been developed directly from carboxylic acids, employing a stoichiometric amount easy-to-access stable triflylpyridinium reagent. The overall transformation proceeds through formation an in situ generated acylpyridinium salt followed by trapping with isocyanoacetates tosylmethyl isocyanide. This broad substrate scope good functional group tolerance (including hindered less reactive substrates or those containing sensitive groups). versatility this newly reaction is illustrated its application gram-scale production FDA-approved prodrug 5-aminolevulinic acid (5-ALA) late-stage functionalization bioactive molecules including estrone, lipoic acid, valproic probenecid. Additionally, process features advantageous recovery reuse base DMAP, underscoring practical benefits.

Язык: Английский

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Merrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines

Green Chemistry, Год журнала: 2019, Номер 21(20), С. 5683 - 5690

Опубликована: Янв. 1, 2019

Metal-free, base-free, biomimetic, and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed for the first time under mild conditions.

Язык: Английский

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Unsymmetrical triazolyl-naphthyridinyl-pyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water

Green Chemistry, Год журнала: 2019, Номер 21(19), С. 5345 - 5351

Опубликована: Янв. 1, 2019

A clean method for the synthesis of functionalized quinolines in water with a recoverable copper catalyst was developed.

Язык: Английский

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Immobilization of manganese dioxide nanoparticles on modified poly 2,4-dichlorostyrene microspheres: a highly efficient and recyclable catalyst for borrowing hydrogen reactions

Organic Chemistry Frontiers, Год журнала: 2019, Номер 6(19), С. 3420 - 3427

Опубликована: Янв. 1, 2019

Modified poly 2,4-dichlorostyrene microspheres were designed and synthesized, proved to be an effective carrier synthesize supported manganese dioxide nanoparticles.

Язык: Английский

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Tandem reaction strategy of the Passerini/Wittig reaction based on the in situ capture of isocyanides: One-pot synthesis of heterocycles

Tetrahedron, Год журнала: 2019, Номер 75(18), С. 2748 - 2754

Опубликована: Март 30, 2019

Язык: Английский

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Iridium Supported on Phosphorus‐Doped Porous Organic Polymers: Active and Recyclable Catalyst for Acceptorless Dehydrogenation and Borrowing Hydrogen Reaction

Advanced Synthesis & Catalysis, Год журнала: 2019, Номер 361(24), С. 5695 - 5703

Опубликована: Окт. 22, 2019

Abstract Iridium‐on‐phosphorus‐doped porous organic polymers (POP−Ir) were developed by anchoring simple iridium onto the skeleton of through coordination bonds. This POP−Ir catalyst, which was thoroughly characterized means EDS, SEM, TEM, XRD, XPS, and FT‐IR, revealed excellent catalytic activity for reaction diphenyl phosphinamide with benzyl alcohols borrowing hydrogen strategy acceptorless dehydrogenation wide functional group tolerance. Moreover, this catalyst could be simply recovered reused at least five times without a significant loss activity, considerable application prospects. The mechanism investigated to further understand system transformations. Overall, has shown high reusability in between phosphinamides alcohols. magnified image

Язык: Английский

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The synthesis and structure of pyridine-oxadiazole iridium complexes and catalytic applications: Non-coordinating-anion-tuned selective C N bond formation

Chinese Chemical Letters, Год журнала: 2019, Номер 31(3), С. 701 - 705

Опубликована: Авг. 28, 2019

Язык: Английский

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Ligand-tuned cobalt-containing coordination polymers and applications in water

Green Chemistry, Год журнала: 2020, Номер 22(23), С. 8452 - 8461

Опубликована: Янв. 1, 2020

Co-CIA could realize the alkylation of ketones and alcohols, alcohols without extra bases organic solvents, while Co-NCIA was effective for synthesis 1-benzyl-2-aryl-1H-benzo[d]imidazoles from various phenylenediamine benzyl in water.

Язык: Английский

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