Organic Chemistry Frontiers, Год журнала: 2020, Номер 7(14), С. 1802 - 1808
Опубликована: Янв. 1, 2020
A
highly
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Язык: Английский
Organic Chemistry Frontiers, Год журнала: 2020, Номер 7(14), С. 1802 - 1808
Опубликована: Янв. 1, 2020
A
highly
efficient
iridium(
Язык: Английский
Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 21(5), С. 879 - 909
Опубликована: Дек. 6, 2022
Transition metal-catalyzed cross-coupling of sp2 C-H bonds with diazo compounds via carbene migratory insertion represents an efficient strategy for the construction C-C and C-heteroatom in organic synthesis. Despite popularity as coupling partners activation, they pose serious safety stability issues due to potential exothermic reactions linked release N2 gas. However, compared compounds, sulfoxonium ylides are generally crystalline solids, more stable, widely used industrial scales, easier/safer prepare. Therefore, recent years have witnessed upsurge employing α-carbonyl alternative surrogate transition activation. Unlike contain inherent serve a partner well weak directing group. This review will summarize progress made both categories reactions.
Язык: Английский
Процитировано
21Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(11), С. 2241 - 2251
Опубликована: Янв. 1, 2024
A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed.
Язык: Английский
Процитировано
5Advanced Synthesis & Catalysis, Год журнала: 2020, Номер 363(2), С. 446 - 452
Опубликована: Дек. 2, 2020
Abstract A formation of fused tricyclic [1,3]oxazino[3,4‐ a ]indol‐1‐ones and dihydropyrimido[1,6‐ ]indol‐1(2 H )‐ones via Rh(III)‐catalyzed [3+3] or [4+2] annulation N ‐methoxy‐1 ‐indole‐1‐carboxamides with sulfoxonium ylides has been developed. These selective reactions were carried out by switching the additives notable features this protocol low catalyst loading broad substrate scope providing corresponding products in up to 99% yields. magnified image
Язык: Английский
Процитировано
31Asian Journal of Organic Chemistry, Год журнала: 2021, Номер 10(7), С. 1671 - 1674
Опубликована: Апрель 15, 2021
Abstract A rhodium‐catalyzed synthesis of isoquinolino[1,2‐ b ]quinazolines via C−H annulation using vinylene carbonate as an oxidizing acetylene surrogate in biomass‐derived γ ‐valerolactone (GVL) has been developed. The reactions proceeded smoothly to give the corresponding products moderate good yields without any external oxidant and base. This protocol can also be applied for 5,6‐dihydro‐8 H ‐isoquinolino[1,2‐ ]quinazolin‐8‐ones.
Язык: Английский
Процитировано
27Advanced Synthesis & Catalysis, Год журнала: 2021, Номер 363(13), С. 3311 - 3317
Опубликована: Май 8, 2021
Abstract A method to synthesize pyrazolo[1,2‐a]cinnolines via rhodium(III)‐catalyzed C−H activation of pyrazolidinones and subsequent [4+2] annulation sulfoxonium ylides was developed. 5‐Substituted or 5,10‐disubstituted could be obtained by slightly adjusting the reaction conditions. Gram‐scale synthesis practical transformations proved practicability this method. The mechanism proposed in article on basis preliminary mechanistic results previous reports. This features simplified operation, metal‐oxidant free, readily available reactants. magnified image
Язык: Английский
Процитировано
25Organic Chemistry Frontiers, Год журнала: 2021, Номер 8(6), С. 1190 - 1196
Опубликована: Янв. 1, 2021
Rh(
Язык: Английский
Процитировано
24Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(13), С. 2248 - 2254
Опубликована: Май 27, 2023
Abstract Herein, an eco‐friendly and atom‐economical electrochemical methodology with isatins 1,2,3,4‐tetrahydroisoquinolines through NHPI/O 2 ‐mediated intermolecular oxidation/annulation is disclosed, leading to a variety of polycyclic quinazolinones in 46–82% yields. This oxidative cyclization proceeded transition metal‐ strong oxidant‐free conditions generated H CO as byproducts. Additionally, late‐stage functionalization broad substrate scope demonstrated the synthetic usefulness this protocol.
Язык: Английский
Процитировано
11Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(8), С. 1863 - 1876
Опубликована: Фев. 21, 2024
Abstract Ru(II)‐catalyzed and solvent‐switched [3+2]‐spiroannulation [4+n] (n=1, 2, 3) annulations of 2‐aryl quinazolinone or 2‐aryl‐2,3‐dihydrophthalazine‐1,4‐diones with ynones alkynyl alcohol 1,3‐diynes under mild reaction conditions have been analyzed. These reactions take place in the presence appropriate solvent features a redox‐neutral pathway. Ynone serves as an ‘atypical one‐carbon unit’ [4+1] annulation generates tetrasubstituted carbon center bearing diverse heterocycles through [3+2] strategies. Post transformations synthesized spiro‐products augments potential developed methodology.
Язык: Английский
Процитировано
4Chemical Communications, Год журнала: 2024, Номер 60(63), С. 8296 - 8299
Опубликована: Янв. 1, 2024
A Co(III)-catalyzed site-selective C5 and C6 benzannulation of substituted pyridones with 1,6-diynes
Язык: Английский
Процитировано
4Chinese Journal of Chemistry, Год журнала: 2020, Номер 38(11), С. 1239 - 1244
Опубликована: Май 17, 2020
Summary of main observation and conclusion Polycyclic fused quinazolinones with anti‐malarial activity were synthesized through tert ‐butyl hydroperoxide (TBHP)‐mediated oxidative decarboxylative cyclization between commercially available isatins cyclic amines in one step. The reaction proceeds smoothly water without additional transition‐metal catalyst, acid base. newly products evaluated to exhibit moderate good against chloroquine drug‐sensitive Plasmodium falciparum 3D7 strain. Additionally, this method also provides direct approach Rutaecarpine yield.
Язык: Английский
Процитировано
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