Progress in heterocyclic chemistry, Год журнала: 2021, Номер unknown, С. 341 - 379
Опубликована: Янв. 1, 2021
Язык: Английский
Progress in heterocyclic chemistry, Год журнала: 2021, Номер unknown, С. 341 - 379
Опубликована: Янв. 1, 2021
Язык: Английский
Chemical Reviews, Год журнала: 2022, Номер 122(15), С. 12544 - 12747
Опубликована: Июль 17, 2022
1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability stabilize ionic species, transfer protons, and engage range of other intermolecular interactions. The use this exponentially increased the past decade become choice some areas, such as C–H functionalization chemistry. In review, following brief history HFIP an overview physical properties, literature examples reactions using or additive are presented, emphasizing effect each reaction.
Язык: Английский
Процитировано
325Organic Letters, Год журнала: 2021, Номер 23(11), С. 4406 - 4410
Опубликована: Май 21, 2021
A novel Rh(III)-catalyzed C–H activation/annulation cascade of indole-enaminones with diazo compounds was reported to construct diversely functionalized carbazole frameworks. The most notable characteristic is that this transformation could smoothly furnish a [5 + 1] cyclization product good excellent yields (up 95%), accompanied by the thorough removal acetyl and N,N-dimethyl groups two substrates from target products, rather than normally expected [4 2] products.
Язык: Английский
Процитировано
52Advanced Synthesis & Catalysis, Год журнала: 2021, Номер 363(13), С. 3311 - 3317
Опубликована: Май 8, 2021
Abstract A method to synthesize pyrazolo[1,2‐a]cinnolines via rhodium(III)‐catalyzed C−H activation of pyrazolidinones and subsequent [4+2] annulation sulfoxonium ylides was developed. 5‐Substituted or 5,10‐disubstituted could be obtained by slightly adjusting the reaction conditions. Gram‐scale synthesis practical transformations proved practicability this method. The mechanism proposed in article on basis preliminary mechanistic results previous reports. This features simplified operation, metal‐oxidant free, readily available reactants. magnified image
Язык: Английский
Процитировано
25The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(6), С. 3845 - 3858
Опубликована: Март 8, 2023
An efficient strategy for the preparation of spirocyclic indole-N-oxide compounds through a Rh(III)-catalyzed [4 + 1] spiroannulation reaction N-aryl nitrones with 2-diazo-1,3-indandiones as C1 synthons under extremely mild conditions is presented. From this reaction, 40 indole-N-oxides were easily obtained in up to 98% yield. In addition, title could be successfully used construction structurally intriguing maleimide-containing fused polycyclic scaffolds via diastereoselective 1,3-dipolar cycloaddition maleimides.
Язык: Английский
Процитировано
11Organic Chemistry Frontiers, Год журнала: 2020, Номер 7(20), С. 3186 - 3192
Опубликована: Янв. 1, 2020
A
removable
directing
group-assisted
Rh(
Язык: Английский
Процитировано
25The Journal of Organic Chemistry, Год журнала: 2021, Номер 86(21), С. 15217 - 15227
Опубликована: Окт. 6, 2021
A facile access to highly fused tetracyclic indeno-1,2-benzothiazines has been established via a Rh(III)-catalyzed C-H bond activation and intramolecular annulation cascade between sulfoximides all-carbon diazo indandiones. This strategy is characterized by the fact that coupling partners do not require preactivation, along with its high efficiency, broad substrate generality, transformation. Particularly, conjugated products demonstrate good optical properties can easily enter cells emit bright fluorescence for live cell imaging.
Язык: Английский
Процитировано
21ACS Catalysis, Год журнала: 2025, Номер unknown, С. 2540 - 2549
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0Russian Journal of Bioorganic Chemistry, Год журнала: 2025, Номер 51(2), С. 373 - 438
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0The Journal of Organic Chemistry, Год журнала: 2020, Номер 85(8), С. 5525 - 5535
Опубликована: Март 23, 2020
Rh(III)-catalyzed C-H activation/annulation of benzimidates with 4-diazoisochroman-3-imines furnished 8-alkoxy-5H-isochromeno[3,4-c]isoquinolines in moderate to excellent yields a broad range substrate scope. The reaction was carried out under mild conditions and could be scaled up practical usage. Similar between 4-diazoisoquinolin-3-ones provided 1-alkoxy-4-arylisoquinolin-3-ols yields. Moreover, the synthesized products conveniently transformed corresponding heterocycles 1,8-naphthyridinone or isochromenopyridinone core, which are privileged structures medicinal chemistry.
Язык: Английский
Процитировано
23The Journal of Organic Chemistry, Год журнала: 2020, Номер 85(12), С. 7905 - 7915
Опубликована: Май 21, 2020
Reported herein are the Rh(III)-catalyzed cascade annulation reactions of N-(pivaloyloxy)benzamides with 1,5-enynes to access diversely substituted aromathecin derivatives involving C-H activation. The developed procedure offers an efficient synthetic tool for assembly a wide range and good atom economy functional group tolerance. key involved in this alkyne insertion aza-Michael addition under oxidant-free mild reaction conditions.
Язык: Английский
Процитировано
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