Non-Palladium-Catalyzed Approach to the Synthesis of (E)-3-(1,3-Diarylallylidene)Oxindoles

Molecules, Год журнала: 2022, Номер 27(16), С. 5304 - 5304

Опубликована: Авг. 19, 2022

Two novel synthetic approaches for synthesizing (E)-3-(1,3-diarylallylidene)oxindoles from oxindole were developed. All previously reported methods 3-(1,3-diarylallylidene)oxindoles utilized palladium-catalyzed reactions as a key step to form this unique skeleton. Despite high efficiency, have limitations in terms of substrate scope. Especially, an iodoaryl moiety cannot be introduced by the previous due its reactivity toward palladium catalyst. Our Knoevenagel/allylic oxidation/Wittig and Knoevenagel/aldol/dehydration strategies complement each other show broad scope, including substrates with groups. The current acetophenones, benzylidene phosphonium ylides, benzaldehydes that are commercially available or easily accessible. Thus, (E)-3-(1,3-diarylallyldiene)oxindoles readily amendable variety derivatives.

Язык: Английский

Five-membered ring systems: pyrroles and benzo analogues

Progress in heterocyclic chemistry, Год журнала: 2021, Номер unknown, С. 119 - 173

Опубликована: Янв. 1, 2021

Язык: Английский