Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Ноя. 5, 2021
Rapid
design,
screening,
and
characterization
of
biorecognition
elements
(BREs)
is
essential
for
the
development
diagnostic
tests
antiviral
therapeutics
needed
to
combat
spread
viruses
such
as
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
To
address
this
need,
we
developed
a
high-throughput
pipeline
combining
in
silico
design
peptide
library
specific
SARS-CoV-2
spike
(S)
protein
microarray
screening
identify
binding
sequences.
Our
optimized
platform
allowed
simultaneous
~
2.5
k
peptides
rapid
identification
sequences
resulting
selection
four
with
nanomolar
affinity
S
protein.
Finally,
demonstrated
successful
integration
one
top
into
an
electrochemical
sensor
clinically
relevant
limit
detection
spiked
saliva.
results
demonstrate
utility
novel
BREs
response
pandemic,
broader
application
future
viral
threats.
Molecules,
Год журнала:
2022,
Номер
27(9), С. 2619 - 2619
Опубликована: Апрель 19, 2022
The
marine
environment
presents
a
favorable
avenue
for
potential
therapeutic
agents
as
reservoir
of
new
bioactive
natural
products.
Due
to
their
numerous
pharmacological
effects,
marine-derived
products—particularly
peptides—have
gained
considerable
attention.
These
peptides
have
shown
broad
spectrum
biological
functions,
such
antimicrobial,
antiviral,
cytotoxic,
immunomodulatory,
and
analgesic
effects.
emergence
virus
strains
viral
resistance
leads
continuing
efforts
develop
more
effective
antiviral
drugs.
Interestingly,
antimicrobial
(AMPs)
that
possess
properties
are
alternatively
regarded
(AVPs)
demonstrate
vast
alternative
peptide-based
drug
candidates
available
infection
treatments.
Hence,
AVPs
obtained
from
various
organisms
been
evaluated.
This
brief
review
features
recent
updates
2011
2021.
Moreover,
the
biosynthesis
this
class
compounds
possible
mechanisms
action
also
discussed.
Selected
possessing
activities
against
important
human
viruses—such
immunodeficiency
viruses,
herpes
simplex
influenza
hepatitis
C
virus,
coronaviruses—are
highlighted
herein.
Optik,
Год журнала:
2024,
Номер
311, С. 171959 - 171959
Опубликована: Июль 11, 2024
The
photocatalytic
degradation
technique
is
one
of
the
suitable
ways
dealing
with
environmental
pollutant
decontamination.
This
study
demonstrates
ability
graphitic
carbon
nitride
(g-C3N4)
nanocomposites
containing
tellurium
(Te)
and
molybdenum
disulfide
(MoS2)
to
photocatalytically
destroy
organic
cationic
methylene
blue
(MB)
dye,
which
primarily
used
in
textile
industry.
Using
alkali
treatment
approach,
layered
was
created.
MoS2
Te,
several
g-C3N4
were
created
using
ultrasonic
calcination
techniques.
After
Te
immobilized
individually,
composites
underwent
a
methodical
characterization
process
utilizing
variety
instruments,
including
XRD
SEM.
2D
nano-g-C3N4
substrate,
photo-catalytic
reaction
MB
observed,
UV
spectrophotometer
determine
absorbance
dye.
0.2
%
MoS2/g-C3N4
5
Te/g-C3N4,
efficiency
dye
(10,
15,
20
mg/L)
solution
examined.
In
comparison
other
produced
nanocomposites,
Te/g-C3N4
composite
shown
have
highest
activity
terms
ability,
about
100
dyes
degraded
less
than
60
minutes.
As
concentration
increased,
steadily
dropped,
rate
around
1.5
mg/L.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Май 19, 2022
The
rapid
evolution
of
highly
infectious
pathogens
is
a
major
threat
to
global
public
health.
In
the
front
line
defense
against
bacteria,
fungi,
and
viruses,
antimicrobial
peptides
(AMPs)
are
naturally
produced
by
all
living
organisms
offer
new
possibilities
for
next-generation
antibiotic
development.
However,
low
yields
difficulties
in
extraction
purification
AMPs
have
hindered
their
industry
scientific
research
applications.
To
overcome
these
barriers,
we
enabled
high
expression
bomidin,
commercial
recombinant
AMP
based
upon
bovine
myeloid
peptide-27.
This
novel
AMP,
which
can
be
expressed
Escherichia
coli
adding
methionine
bomidin
sequence,
bulk
more
biologically
active
than
chemically
synthesized
AMPs.
We
verified
function
variety
bacteria
enveloped
including
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
herpes
simplex
virus
(HSV),
dengue
(DENV),
chikungunya
(CHIKV).
Furthermore,
on
molecular
modeling
membrane
lipids,
elucidated
possible
mechanism
disrupts
bacterial
viral
membranes.
Thus,
obtained
with
an
optimized,
efficient
heterologous
system
potential
therapeutic
application
wide
range
life-threatening
pathogens.
New Journal of Chemistry,
Год журнала:
2022,
Номер
46(10), С. 4911 - 4926
Опубликована: Янв. 1, 2022
Two
novel
copper(
ii
)
Schiff
base
complexes,
[Cu(L
1
2
]
(1)
and
)(CH
3
OH)(Cl)]
(2)
of
[(
Z
)-(5-chloro-2-((3,5-dichloro-2-hydroxybenzylidene)amino)phenyl)(phenyl)methanone
(L
H)
(
)-(2((5-bromo-2-hydroxybenzylidene)amino-5-chlorophenyl)(phenyl)methanone)(L
H)],
have
been
designed,
synthesized
characterized.
Journal of Medical Virology,
Год журнала:
2023,
Номер
95(3)
Опубликована: Март 1, 2023
Abstract
Peptides
are
promising
therapeutic
agents
for
COVID‐19
because
of
their
specificity,
easy
synthesis,
and
ability
to
be
fine‐tuned.
We
previously
demonstrated
that
a
cell‐permeable
peptide
corresponding
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
Spike
C‐terminal
domain
(CD)
inhibits
interaction
between
viral
spike
nucleocapsid
proteins
results
in
SARS‐CoV‐2
replication
vitro.
Here,
we
used
docking
studies
design
R‐t‐Spike
CD(D),
more
potent
short
cell‐penetrating
composed
all
D‐form
amino
acids
evaluated
its
inhibitory
effect
against
S
clade
other
variants.
CD(D)
was
internalized
into
Vero
cells
Calu‐3
suppressed
clade,
delta
variant,
omicron
variant
with
higher
potency
than
original
peptide.
In
hemizygous
K18‐hACE2
mice,
intratracheal
administration
effectively
delivered
trachea
lungs,
whereas
intranasal
mostly
upper
system
stomach,
small
amount
lungs.
Administration
by
either
route
reduced
loads
mouse
lungs
turbinates.
Furthermore,
intranasally
administered
mitigated
pathological
change
increased
survival
mice
after
infection
or
variant.
Our
data
suggest
has
potential
as
agent
infection.
Briefings in Bioinformatics,
Год журнала:
2021,
Номер
23(1)
Опубликована: Сен. 9, 2021
Coronavirus
disease
2019
(COVID-19)
has
impacted
public
health
as
well
societal
and
economic
well-being.
In
the
last
two
decades,
various
prediction
algorithms
tools
have
been
developed
for
predicting
antiviral
peptides
(AVPs).
The
current
COVID-19
pandemic
underscored
need
to
develop
more
efficient
accurate
machine
learning
(ML)-based
rapid
identification
of
therapeutic
against
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2).
Several
peptide-based
ML
approaches,
including
anti-coronavirus
(ACVPs),
IL-6
inducing
epitopes
other
targeting
SARS-CoV-2,
implemented
in
therapeutics.
Owing
growing
interest
field,
it
is
crucial
systematically
compare
existing
based
on
their
performances.
Accordingly,
we
comprehensively
evaluated
state-of-the-art
AVP
predictors
coronaviruses
terms
core
algorithms,
feature
encoding
schemes,
performance
evaluation
metrics
software
usability.
A
comprehensive
assessment
was
then
conducted
evaluate
robustness
scalability
using
well-constructed
independent
validation
datasets.
Additionally,
discussed
advantages
disadvantages
methods,
providing
useful
insights
into
development
novel
computational
characterizing
identifying
or
ACVPs.
gained
from
this
review
are
anticipated
provide
critical
guidance
scientific
community
design
next-generation
silico
SARS-CoV-2.