Interactions of Micro- and Nanoplastics with Biomolecules: From Public Health to Protein Corona Effect and Beyond DOI
Tao Zhang, Zi Wang, Yue Wu

и другие.

The Journal of Physical Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Micro- and nanoplastics (M/NPs), as ubiquitous global environmental pollutants, have garnered increasing attention due to their pervasive presence. These particles can interact with biological molecules through various mechanisms, subsequently inducing potential toxic effects on living organisms. This review investigates the hazards of M/NPs interactions membranes proteins, focusing interaction mechanisms biomolecular structure function. Specifically, we summarize exposure pathways harms M/NPs, which enter human body ingestion, inhalation, skin contact, potentially causing toxicity, inflammation responses, oxidative stress, endocrine disruption. Additionally, highlight between membranes, induce structural changes, including membrane thickening, increased fluidity, pore formation, thereby compromising integrity affecting cellular health. Besides, emphasize suggesting that protein changes corona formation influence stress responses cytotoxicity, impacting functions viability. Ultimately, suggestions outlooks for further research are proposed. Overall, this systematically summarizes current biomolecules, effects, providing researchers a comprehensive understanding field.

Язык: Английский

Interactions of Micro- and Nanoplastics with Biomolecules: From Public Health to Protein Corona Effect and Beyond DOI
Tao Zhang, Zi Wang, Yue Wu

и другие.

The Journal of Physical Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Май 25, 2025

Micro- and nanoplastics (M/NPs), as ubiquitous global environmental pollutants, have garnered increasing attention due to their pervasive presence. These particles can interact with biological molecules through various mechanisms, subsequently inducing potential toxic effects on living organisms. This review investigates the hazards of M/NPs interactions membranes proteins, focusing interaction mechanisms biomolecular structure function. Specifically, we summarize exposure pathways harms M/NPs, which enter human body ingestion, inhalation, skin contact, potentially causing toxicity, inflammation responses, oxidative stress, endocrine disruption. Additionally, highlight between membranes, induce structural changes, including membrane thickening, increased fluidity, pore formation, thereby compromising integrity affecting cellular health. Besides, emphasize suggesting that protein changes corona formation influence stress responses cytotoxicity, impacting functions viability. Ultimately, suggestions outlooks for further research are proposed. Overall, this systematically summarizes current biomolecules, effects, providing researchers a comprehensive understanding field.

Язык: Английский

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