Box-Behnken Design Assisted Optimization and Characterization of Chitosan Film for Simultaneous Topical Delivery of Ascorbic Acid and Metronidazole DOI Creative Commons
Barkat Ali Khan,

Pakorn Kraisit,

Supaporn Santhan

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 562 - 562

Опубликована: Апрель 24, 2025

Background/Objectives: The objective of this study was to develop chitosan films plasticized with glycerol for the topical delivery ascorbic acid and metronidazole. Methods: were prepared using a casting technique in which an aqueous solution served as solvent, eliminating need additional mineral or organic acids. influence compositions on film characteristics—specifically mechanical properties surface pH—was examined, optimized formulation identified Box-Behnken design-response methodology. Relevant characterization techniques vitro evaluations conducted assess performance formulation. Results: Results showed that both contributed plasticization films. Fourier-transform infrared spectroscopic analysis revealed formation ascorbate interactions between glycerol. In addition, thermogram powder X-ray diffractogram demonstrated alterations thermal behavior crystallinity embedded bioactive compounds. developed possessed preferred swelling capacity. Moreover, release studies co-release pattern, delivering compounds simultaneously. Conclusions: These findings suggest chitosan-based could serve promising platform delivery.

Язык: Английский

Box-Behnken Design Assisted Optimization and Characterization of Chitosan Film for Simultaneous Topical Delivery of Ascorbic Acid and Metronidazole DOI Creative Commons
Barkat Ali Khan,

Pakorn Kraisit,

Supaporn Santhan

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 562 - 562

Опубликована: Апрель 24, 2025

Background/Objectives: The objective of this study was to develop chitosan films plasticized with glycerol for the topical delivery ascorbic acid and metronidazole. Methods: were prepared using a casting technique in which an aqueous solution served as solvent, eliminating need additional mineral or organic acids. influence compositions on film characteristics—specifically mechanical properties surface pH—was examined, optimized formulation identified Box-Behnken design-response methodology. Relevant characterization techniques vitro evaluations conducted assess performance formulation. Results: Results showed that both contributed plasticization films. Fourier-transform infrared spectroscopic analysis revealed formation ascorbate interactions between glycerol. In addition, thermogram powder X-ray diffractogram demonstrated alterations thermal behavior crystallinity embedded bioactive compounds. developed possessed preferred swelling capacity. Moreover, release studies co-release pattern, delivering compounds simultaneously. Conclusions: These findings suggest chitosan-based could serve promising platform delivery.

Язык: Английский

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