Interaction of Metal Ion Stabilized Oligomeric Dipeptide with Lipid Membrane: Concurrent Observations of Supported Lipid Membrane, Wetting, and Uptake DOI

Priyanka Nath,

Debanjan Bagchi,

Avijit Maity

и другие.

The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер unknown, С. 5531 - 5537

Опубликована: Май 27, 2025

The interaction of biomolecules with cell membranes is crucial due to their important role in governing cellular function and membrane dynamics. However, most the studies predominantly focus on monomeric forms lipid membranes, leaving effects cytotoxic oligomeric self-aggregates largely unexplored. In this study, we report that metal ion stabilized intermediates diphenylalanine cause wetting uptake, induce coalescence, resulting significant structural alterations varying surface charges. On other hand, fibrillar morphology facilitates formation supported phospholipid through liposome deformation. These insights open new research directions profound implications for biomedicine nanotechnology help fundamental biological understanding.

Язык: Английский

Coordination-driven self-assembly of biomolecules and metal ions: Advances in methodology and applications DOI
Yue Su, Yiting Liu, Yu Lin Zhong

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 527, С. 216403 - 216403

Опубликована: Дек. 26, 2024

Язык: Английский

Процитировано

4
Visual Monitoring of Biomolecular Self-Assembly Dynamics and Imaging of Protein Aggregates by Distinct Emission of a Unique Hydrophobic Carbon Dot DOI

Debanjan Bagchi,

Avijit Maity, K S Saini

и другие.

The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер unknown, С. 3501 - 3508

Опубликована: Март 31, 2025

Here, we report a novel and unique application of special hydrophobic carbon dot (HCD) to monitor biomolecular self-assembly, along with the detection metastable intermediates self-aggregates. We exploited restricted rotation S–S bond HCD synthesized from dithiosalicylic acid melamine illuminate different emission behaviors during self-assembly amino acids proteins. The that exhibits blue in droplets or protein aggregates dynamically changes its red over time course process. This distinct change can be visualized by naked eye under UV lamp. ability distinguish self-aggregated structures dynamics utilized for visual uncontrolled aggregation proteins peptides related neurodegenerative diseases like Alzheimer's disease Parkinson's disease.

Язык: Английский

Процитировано

0
Interaction of Metal Ion Stabilized Oligomeric Dipeptide with Lipid Membrane: Concurrent Observations of Supported Lipid Membrane, Wetting, and Uptake DOI

Priyanka Nath,

Debanjan Bagchi,

Avijit Maity

и другие.

The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер unknown, С. 5531 - 5537

Опубликована: Май 27, 2025

The interaction of biomolecules with cell membranes is crucial due to their important role in governing cellular function and membrane dynamics. However, most the studies predominantly focus on monomeric forms lipid membranes, leaving effects cytotoxic oligomeric self-aggregates largely unexplored. In this study, we report that metal ion stabilized intermediates diphenylalanine cause wetting uptake, induce coalescence, resulting significant structural alterations varying surface charges. On other hand, fibrillar morphology facilitates formation supported phospholipid through liposome deformation. These insights open new research directions profound implications for biomedicine nanotechnology help fundamental biological understanding.

Язык: Английский

Процитировано

0