Materials,
Год журнала:
2023,
Номер
16(23), С. 7467 - 7467
Опубликована: Ноя. 30, 2023
In
this
paper,
a
state-of-the-art
multi-detection
gel
permeation
chromatography/size
exclusion
chromatography
(GPC/SEC)
system
including
multi-angle
laser
light
scattering
(MALLS)
is
applied
to
monitor
radiation-induced
synthesis
of
internally
crosslinked
nanostructures
from
poly(acrylic
acid)
(PAA).
The
aim
demonstrate
that
modern
tool
yields
more
detailed
picture
reaction
mechanism
and
product
structure
than
the
techniques
used
date.
prevailing
intramolecular
crosslinking
narrows
molecular
weight
distribution
Mw/Mn
=
3.0
1.6
for
structures.
A
clear
trend
over
0.7
0.5
in
Mark-Houwink
exponent
decrease
Rg/Rh
1.7
1.0
point
formation
nanogels,
rigid
less
permeable
starting
coils.
Changes
coil
contraction
factor
(g'
[η]irradiated/[η]linear)
as
function
radical
density
revealed
existence
two
modes
crosslinking,
initial
one
(up
0.075
radicals
per
monomer
unit)
where
compactness
products
changes
strongly
with
progressing
second
further
compacting
suppressed
by
lower
flexibility
partially
chain
segments.
This
indicates
transition
soft,
still
crosslinkable
nanogels
structures,
prone
loop
formation.
Our
findings
provide
means
tailored
design
new
PAA
nanomaterials.
Soft Matter,
Год журнала:
2024,
Номер
20(29), С. 5836 - 5847
Опубликована: Янв. 1, 2024
The
structures
of
single
microgels
and
microgel
arrays
at
the
air/water
interface
were
directly
visualized
correlated
with
π
–
A
isotherms
to
understand
compression
behavior
soft
deformable
interface.
Chemical Communications,
Год журнала:
2023,
Номер
59(89), С. 13289 - 13292
Опубликована: Янв. 1, 2023
The
compression
of
deformed
hydrogel
microspheres
(microgels)
at
air/water
interfaces
was
investigated
using
a
Langmuir-Blodgett
trough
with
simultaneous
in
situ
visualization
the
process
fluorescent
microscope.
relationship
between
structure
microgel
arrays
and
behavior
clarified
microgels
different
degrees
crosslinking.
Cells,
Год журнала:
2024,
Номер
13(11), С. 908 - 908
Опубликована: Май 24, 2024
The
future
of
drug
delivery
offers
immense
potential
for
the
creation
nanoplatforms
based
on
nanogels.
Nanogels
present
a
significant
possibility
pharmaceutical
advancements
because
their
excellent
stability
and
effective
drug-loading
capability
both
hydrophobic
hydrophilic
agents.
As
multifunctional
systems,
composite
nanogels
demonstrate
capacity
to
carry
genes,
drugs,
diagnostic
agents
while
offering
perfect
platform
theranostic
multimodal
applications.
can
achieve
diverse
responsiveness
enable
stimuli-responsive
release
chemo-/immunotherapy
drugs
thus
reprogramming
cells
within
TME
in
order
inhibit
tumor
proliferation,
progression,
metastasis.
In
active
targeting
boost
accumulation
at
target
sites,
particular
ligands
be
added
improve
therapeutic
outcomes
enhance
precision
cancer
therapy.
Modern
“immune-specific”
also
have
extra
sophisticated
tissue-editing
properties.
Consequently,
introduction
nanogel-based
system
improves
targeted
distribution
immunotherapy
combinational
treatments,
thereby
increasing
effectiveness
When
functional
microgels
are
synthesized
via
radical
copolymerization,
spatial
gradients
of
groups
often
form
due
to
a
difference
in
reactivity
ratios
between
monomer
and
comonomer.
In
this
study,
we
systematically
investigated
the
effect
decreasing
gradient
charged
from
core
shell
on
their
surface
properties,
which
crucial
for
colloidal
particles,
through
analysis
interfacial
electrokinetic
phenomena
using
Ohshima's
equation.
A
series
electrophoretic
analyses
combined
with
dynamic
light
scattering
revealed
that
undergoes
multistep
collapse
during
particle-size
reduction
dehydration
upon
increasing
temperature.
Furthermore,
more
complicated
hierarchical
within
was
elucidated
by
quantitatively
evaluating
changes
properties
precipitation
polymerization
based
phenomena.
The Journal of Chemical Physics,
Год журнала:
2025,
Номер
162(18)
Опубликована: Май 13, 2025
Poly(N-isopropylacrylamide)
(pNIPAM)
microgels
exhibit
a
reversible
thermoresponsive
behavior,
undergoing
volume
phase
transition.
This
property
makes
pNIPAM
highly
appealing
for
diverse
applications,
including
drug
delivery,
tissue
engineering,
and
sensors,
where
temperature-triggered
changes
in
size,
charge,
mechanical
properties
are
advantageous.
However,
plethora
of
data
available
the
literature
regarding
relationship
between
crosslinking
density
above-mentioned
necessitates
consolidation
re-examination.
study
aims
to
address
two
key
objectives:
(1)
elucidate
size/electrophoretic
mobility
microgels,
building
upon
existing
knowledge,
(2)
examine
influence
on
transition
temperatures,
particularly
electrokinetic
temperature,
which
is
not
well
explored
understood.
To
achieve
these
objectives,
we
synthesized
20
batches
using
distinct
synthesis
routes:
18
via
conventional
one-pot
synthesis,
with
triplicate
replicates
six
densities,
semi-batch
duplicate
replicate
one
density.
These
were
characterized
combination
dynamic
light
scattering
determine
size
electrophoretic
analyze
mobility,
atomic
force
microscopy
evaluate
structural
morphology
assess
stiffness.
The
insights
from
characterization
techniques
enhance
our
understanding
how
influences
physical
potentially
creating
pathway
rational
design
tailored
specific
applications.
Colloid & Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 18, 2024
Abstract
We
analyze
the
swelling
behavior
of
N
-isopropylacrylamide
(NIPAM)-based
microgels
incorporating
non-thermoresponsive
comonomer
-
tert
-butylacrylamide
(NtBAM)
using
photon
correlation
spectroscopy
(PCS)
and
atomic
force
microscopy
(AFM).
Previous
thermodynamic
analysis
PNIPAM-co-NtBAM
microgel
relied
on
classical
Flory-Rehner
theory.
However,
this
approach
struggled
to
accurately
describe
curves
at
higher
NtBAM
content.
Our
present
work
combines
original
expression
for
Flory-Huggins
interaction
parameter
$$\chi
_{FH}$$
χFH
with
a
recently
adapted
Hill-like
model
_{Hill}$$
Hill
that
accounts
cooperative
effects
in
volume
phase
transition
poly(NIPAM)
microgels.
This
outperforms
other
methods
fitting
quality.
The
observed
results
are
revealing
an
exponential
decrease
hydrodynamic
radius
upon
increasing
content
swollen
In
addition,
decay
number
water
molecules
leaving
polymer
chain
during
is
found,
which
can
be
attributed
steric
influence
one
monomer
hydration
neighboring
NIPAM
monomers.
molar
enthalpy
$$\Delta
H_{SP}=
\text
{-49
kJ
/
mol}$$
ΔHSP=-49
mol
entropy
S_{SP}
=
{-177
J
/(
mol
K)}$$
S-177
K)
were
obtained
from
fits
curves.
Graphical
Macromolecules,
Год журнала:
2024,
Номер
57(3), С. 1248 - 1257
Опубликована: Янв. 16, 2024
An
efficient
strategy
is
reported
for
preparing
smart
microgels
through
in
situ
cross-linking
thermally
induced
aggregates
from
thermoresponsive
dendrimers
aqueous
media
via
photoinduced
[2
+
2]
cycloaddition.
These
are
composed
of
a
fluorescent
4,4′,4″-nitrilotribenzamide
core
and
decorated
with
three
dendritic
oligoethylene
glycol-carrying
cinnamate
moieties.
The
photocycloaddition
approach
fast
straight
without
the
use
any
additional
additives
such
as
initiators,
agents,
or
surfactants,
which
affords
narrowly
dispersed
controllable
sizes.
inherit
characteristic
thermoresponsiveness
parent
dendrimer
undergo
reversible
volume
phase
transitions
solutions
tailorable
deswelling
ratios.
In
contrast
to
fluorescence
silent
due
quenching
moieties
core,
show
strong
blue
since
this
effect
was
vanished
into
nonconjugated
cyclobutanes.
By
further
loading
BODIPY
dyes,
can
be
modulated
ratiometrically
green
transitions.
new
dendrimer-based
densely
packed
architectures
provided
supplemental
entities
existing
fabricated
linear
polymers,
their
tunable
would
promote
fascinating
applications
cargo
delivery
nanosensing.
